Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
Publications
Publications from current research groups. For publications from former groups, see alumni pages
1993
The molecular organization of tight junctions.
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development.
Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development.
Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.
Oncogene,
1993 Jan 1;
8
(1): 125-132