Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
Publications
Publications from current research groups. For publications from former groups, see alumni pages
2012
Amino acid signaling in high definition.
Cdc42 oscillations in yeasts.
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc.
A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.
Fission yeast: in shape to divide.
Myosin Vs organize actin cables in fission yeast.
The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Being at the right place at the right time.
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.
Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.
Molecular biology. Outsourcing genome protection.
Cartwheel architecture of Trichonympha basal body.
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex.
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling.
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
piRNAs and their involvement in male germline development in mice.
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles.