Publications

Publications from current research groups. For publications from former groups, see alumni pages

2004

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD.

Nature, 2004 Nov 3; 432 (7015): 406-411

DOI: 10.1038/nature03114

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN

Nat Cell Biol, 2004 Nov; 6 (11): 1122-1128

DOI: 10.1038/ncb1183

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase.

Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy BG.

J Biol Chem, 2004 Jun 17; 279 (41): 42907-42915

DOI: 10.1074/jbc.m406135200

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

Audhya A, Loewith R, Parsons AB, Gao L, Tabuchi M, Zhou H, Boone C, Hall MN, Emr SD

EMBO J, 2004 Oct 1; 23 (19): 3747-3757

DOI: 10.1038/sj.emboj.7600384

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.

Pillai RS, Artus CG, Filipowicz W

RNA, 2004 Oct; 10 (10): 1518-1525

DOI: 10.1261/rna.7131604

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.

Schümperli D, Pillai RS

Cell Mol Life Sci, 2004 Oct; 61 (19-20): 2560-2570

DOI: 10.1007/s00018-004-4190-0

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T.

EMBO J, 2004 Sep 2; 23 (18): 3689-3699

DOI: 10.1038/sj.emboj.7600363

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.

Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.

J Cell Biol, 2004 Sep 1; 166 (6): 801-813

DOI: 10.1083/jcb.200405128

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer.

Halazonetis TD.

DNA Repair (Amst), 2004 Aug 1; 3 (8-9): 1057-1062

DOI: 10.1016/j.dnarep.2004.03.036

53BP1, an activator of ATM in response to DNA damage.

Mochan TA, Venere M, DiTullio RA, Halazonetis TD.

DNA Repair (Amst), 2004 Aug 1; 3 (8-9): 945-952

DOI: 10.1016/j.dnarep.2004.03.017

Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD.

Structure, 2004 Jul 1; 12 (7): 1237-1243

DOI: 10.1016/j.str.2004.05.007

Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.

Kovári J, Barabás O, Takács E, Békési A, Dubrovay Z, Pongrácz V, Zagyva I, Imre T, Szabó P, Vértessy BG.

J Biol Chem, 2004 Jan 14; 279 (17): 17932-17944

DOI: 10.1074/jbc.m313643200

p53 and stress in the ER.

Stavridi ES, Halazonetis TD.

Genes Dev, 2004 Feb 1; 18 (3): 241-244

DOI: 10.1101/gad.1181704

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