The A-C linker controls centriole structural integrity and duplication.
Bournonville L , Laporte MH , Borgers S , Guichard P , Hamel V
Nat Commun
2025 Jul 24 ;
16
(
1 ):
6836
A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Billmann M , Costanzo M , Zhang X , Hassan AZ , Rahman M , Brown KR , Chan KS , Tong AHY , Pons C , Ward HN , Ross C , van Leeuwen J , Aregger M , Lawson KA , Mair B , Roth AF , Sen NE , Forster D , Tan G , Mero P , Masud SN , Lee Y , Aguilera-Uribe M , Usaj M , Almeida SMT , Aulakh K , Bhojoo U , Birkadze S , Budijono N , Cai X , Caumanns JJ , Chandrashekhar M , Chang D , Climie R , Dasgupta K , Drazic A , Rojas Echenique JI , Gacesa R , Granda Farias A , Habsid A , Horecka I , Kantautas K , Ji F , Kim DK , Lee SY , Liang W , Lim J , Lin K , Lu X , Nami B , Nixon A , Mikolajewicz N , Nedyalkova L , Rohde T , Sartori Rodrigues M , Soste M , Schultz E , Wang W , Seetharaman A , Shuteriqi E , Sizova O , Thomson Taylor D , Tereshchenko M , Tieu D , Turowec J , Ubhi T , Varland S , Wang KE , Wang ZY , Wei J , Xiao YX , Brown GW , Cravatt BF , Dixon SJ , Wyatt HDM , Röst HL , Roth FP , Xia T , Bader GD , Loewith R , Davis NG , Andrews B , Myers CL , Moffat J , Boone C
Ubiquitin-dependent proteolysis of KNL2 driven by APC/CCDC20 is critical for centromere integrity and mitotic fidelity.
Kalidass M , Jarubula VG , Ratnikava M , Chandra JR , Le Goff S , Probst AV , Esposito S , Grasser KD , Bruckmann A , Gagneux JF , Prosée RF , Rutten T , Schubert V , Demidov D , Lechner E , Steiner FA , Genschik P , Lermontova I
Plant Cell
2025 Jul 1 ;
37
(
7 )
Paracingulin controls the junctional accumulation of nonmuscle myosin-2 in endothelial cells in vivo.
Rouaud F , Mean I , Jond L , Citi S
MicroPubl Biol
2025 ;
2025
The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages.
Bertiaux E , Louvel V , McCafferty CL , van den Hoek H , Batman U , Mukherjee S , Bournonville L , Mercey O , Mean I , Müller A , Van der Stappen P , Buss G , Daraspe J , Genoud C , Stearns T , Engel BD , Hamel V , Guichard P
C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly.
Pfister JA , Agostini L , Bournonville L , Perrier A , Sankaralingam P , Bell ZG , Hamel V , Guichard P , Biertümpfel C , Mizuno N , O'Connell KF
Nat Commun
2025 Jun 5 ;
16
(
1 ):
5220
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse
Sajjita Saha , Aiswarya Sajeevan , Laura Merlini , Vincent Vincenzetti , Sophie G Martin
bioRxiv
2025.05.05.652171 ;
High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction
Valentine Thomas , Hikari Mase , Laetitia Michon , Andrea Picco , Marko Kaksonen , Sophie G Martin
bioRxiv
2025.04.29.651207 ;
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport.
Rouaud F , Meens MJ , Yvon R , Hautefort A , Legouis D , Mean I , Jond L , Maillard M , Kwak BR , Moll S , Seigneux S , Feraille E , Citi S
Am J Physiol Renal Physiol
2025 Jun 1 ;
328
(
6 ):
F737 -
F751
Uncovering the mechanism for polar sequestration of the major bacterial sugar regulator by high-throughput screens and 3D interaction modeling.
Albocher-Kedem N , Heidenreich M , Fadel A , Sirotkin E , Goldberger O , Nussbaum-Shochat A , Levy ED , Schueler-Furman O , Schuldiner M , Amster-Choder O
Cell Rep
2025 Mar 25 ;
44
(
3 ):
115436
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed.
Sobkowiak K , Kohzaki M , Böhm R , Mailler J , Huber F , Emamzadah S , Tropia L , Hiller S , Halazonetis TD
Cell Rep
2025 Apr 22 ;
44
(
4 ):
115431
SSUP-72/PINN-1 coordinates RNA-polymerase II 3' pausing and developmental gene expression in C. elegans.
Stubbe FX , Ponsard P , Steiner FA , Hermand D
Nat Commun
2025 Mar 17 ;
16
(
1 ):
2624
A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics.
Maupérin M , Sun Y , Glandorf T , Oswald TA , Klatt N , Geil B , Mutero-Maeda A , Méan I , Jond L , Janshoff A , Yan J , Citi S
Nat Commun
2025 Mar 13 ;
16
(
1 ):
2514
Telomeric transposons are pervasive in linear bacterial genomes.
Hsieh SC , Fülöp M , Schargel R , Petassi MT , Barabas O , Peters JE
Science
2025 Mar 28 ;
387
(
6741 ):
eadp1973
Rapid and sensitive protein complex alignment with Foldseek-Multimer.
Kim W , Mirdita M , Levy Karin E , Gilchrist CLM , Schweke H , Söding J , Levy ED , Steinegger M
Nat Methods
2025 Mar ;
22
(
3 ):
469 -
472
Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability.
von Glasenapp V , C Almeida A , Chang D , Gasic I , Winssinger N , Gotta M
Nat Commun
2025 Feb 19 ;
16
(
1 ):
1599
sqt-3(sc63) is an alternative CRISPR/Cas9 co-conversion marker in Caenorhabditis elegans.
Özdemir I , Steiner FA
MicroPubl Biol
2025 ;
2025
Structural determinants of co-translational protein complex assembly.
Mallik S , Venezian J , Lobov A , Heidenreich M , Garcia-Seisdedos H , Yeates TO , Shiber A , Levy ED
Cell
2025 Feb 6 ;
188
(
3 ):
764 -
777.e22
Positively charged specificity site in cyclin B1 is essential for mitotic fidelity.
Heinzle C , Höfler A , Yu J , Heid P , Kremer N , Schunk R , Stengel F , Bange T , Boland A , Mayer TU
Nat Commun
2025 Jan 20 ;
16
(
1 ):
853
A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I.
Schunk R , Halder M , Schäfer M , Johannes E , Heim A , Boland A , Mayer TU
EMBO Rep
2025 Feb ;
26
(
3 ):
768 -
790
