ORCID: https://orcid.org/0000-0002-8145-3364

Twitter: @BorisSieber

Bluesky: @borissieber.bsky.social

Background

I obtained my MSc in Biology at the University of Geneva, which I completed with a lab experience on centriole formation in the lab of Jordan Raff at the Dunn School of Pathology, University of Oxford. I remained in the same institute to pursue a PhD in Molecular Cell Biology in the lab of Matthew Freeman. I discovered that ERK1/2 phosphorylate the rhomboid-like protein iRhom2 to induce a positive feedback loop promoting lung tumour growth. 

Combining my passions for both the cytoskeleton and MAPK signalling, I joined the lab of Sophie Martin in February 2021. My postdoc project focuses on how GPCR-driven pheromone signalling induces actin-dependent shmoo formation in fission yeast. To characterise the interactome of the pheromone signalling pathway, I designed a high-throughput screen using both immunoprecipitation – mass spectrometry (IP-MS) and AlphaFold-Multimer.

Publication list

Sieber, B.*, Coronas-Serna, J.M.*, and Martin, S.G. (2023). A focus on yeast mating: From pheromone signaling to cell-cell fusion. Semin. Cell Dev. Biol. 133, 83–95. https://doi.org/10.1016/j.semcdb.2022.02.003

Sieber, B.*, Lu, F.*, Stribbling, S.M., Grieve, A.G., Ryan, A.J., and Freeman, M. (2022). iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells. J. Cell Sci. https://doi.org/10.1242/jcs.259949

Gartenmann, L.*, Vicente, C.C.*, Wainman, A., Novak, Z.A., Sieber, B., Richens, J.H., and Raff, J.W. (2020). Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole/centrosome assembly. J. Cell Sci. https://doi.org/10.1242/jcs.244574

Künzel, U., Grieve, A.G., Meng, Y., Sieber, B., Cowley, S.A., and Freeman, M. (2018). FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. eLife 7, e35012. https://doi.org/10.7554/eLife.35012 

Grieve, A.G.*, Xu, H.*, Künzel, U., Bambrough, P., Sieber, B., and Freeman, M. (2017). Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. eLife 6. https://doi.org/10.7554/eLife.23968

Saurya, S., Roque, H., Novak, Z.A., Wainman, A., Aydogan, M.G., Volanakis, A., Sieber, B., Pinto, D.M.S., and Raff, J.W. (2016). Drosophila Ana1 is required for centrosome assembly and centriole elongation. J. Cell Sci. 129, 2514–2525. https://doi.org/10.1242/jcs.186460