Sophie Martin

Publications

2024

Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast
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bioRxiv, ;
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
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PLoS Biol, ; 22 (12): e3002963
Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival.
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Nat Commun, ; 15 (1): 8363

2023

Revised fission yeast gene and allele nomenclature guidelines for machine readability.
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Genetics, ; 225 (3)
A focus on yeast mating: From pheromone signaling to cell-cell fusion.
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Semin Cell Dev Biol, ; 133 : 83-95

2022

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion.
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Curr Biol, ; 32 (21): 4752-4761.e10
mNG-tagged fusion proteins and nanobodies to visualize tropomyosins in yeast and mammalian cells.
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J Cell Sci, ; 135 (18)
Actin assembly requirements of the formin Fus1 to build the fusion focus.
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J Cell Sci, ; 135 (13)

2021

Going with the membrane flow: the impact of polarized secretion on bulk plasma membrane flows.
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FEBS J, ; 290 (3): 669-676
Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion.
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J Cell Biol, ; 220 (10)
Cell patterning by secretion-induced plasma membrane flows.
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Sci Adv, ; 7 (38): eabg6718
Direct and indirect regulation of Pom1 cell size pathway by the protein phosphatase 2C Ptc1.
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Mol Biol Cell, ; 32 (8): 703-711
Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance.
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PLoS Biol, ; 19 (1): e3001067

2020

Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
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Cells, ; 9 (9)
Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition.
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J Cell Biol, ; 219 (6)
DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
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Mol Biol Cell, ; 31 (9): 917-929
Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase.
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PLoS Biol, ; 18 (1): e3000600
A toolbox of stable integration vectors in the fission yeast Schizosaccharomyces pombe.
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J Cell Sci, ; 133 (1)

2019

Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.
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Curr Biol, ; 29 (19): 3165-3176.e6
Molecular mechanisms of chemotropism and cell fusion in unicellular fungi.
J Cell Sci, ; 132 (11)
Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size.
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Elife, ; 8
Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to environmental stimuli.
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Mol Biol Cell, ; 30 (8): 975-991

2018

Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
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J Cell Biol, ; 217 (12): 4215-4229
Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.
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Nature, ; 560 (7718): 397-400
Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks.
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PLoS Comput Biol, ; 14 (7): e1006317
Dynamic visits of cortical structures probe for cell size.
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J Cell Biol, ; 217 (5): 1559-1561
Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.
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J Cell Biol, ; 217 (4): 1467-1483

2017

Live Cell Imaging of the Schizosaccharomyces pombe Sexual Life Cycle.
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Cold Spring Harb Protoc, ; 2017 (10): pdb.prot090225
A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
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PLoS Genet, ; 13 (4): e1006721
Nuclear displacement and fluorescence recovery after photobleaching (FRAP) assays to study division site placement and cytokinesis in fission yeast.
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Methods Cell Biol, ; 137 : 341-353

2016

Role and organization of the actin cytoskeleton during cell-cell fusion.
Semin Cell Dev Biol, ; 60 : 121-126
Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.
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Genes Dev, ; 30 (19): 2226-2239
Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.
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Curr Biol, ; 26 (8): 1117-1125
Microscopy of Fission Yeast Sexual Lifecycle.
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J Vis Exp, ; (109)

2015

Editorial overview: Eukaryotic microbes: models and beyond.
Curr Opin Microbiol, ; 28 : v-vi
The DYRK-family kinase Pom1 phosphorylates the F-BAR protein Cdc15 to prevent division at cell poles.
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J Cell Biol, ; 211 (3): 653-668
Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry.
Bioessays, ; 37 (11): 1193-1201
PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
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Nat Commun, ; 6 : 8445
Pom1 gradient buffering through intermolecular auto-phosphorylation.
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Mol Syst Biol, ; 11 (7): 818
Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.
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Mol Cell Biol, ; 35 (9): 1533-1542
Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.
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PLoS Biol, ; 13 (4): e1002097
A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.
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J Cell Biol, ; 208 (7): 897-911

2014

Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.
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J Cell Biol, ; 206 (1): 61-77
The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.
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J Cell Biol, ; 205 (3): 357-375
The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
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J Cell Sci, ; 127 (Pt 9): 2005-2016
Yeasts as models in cell biology.
FEMS Microbiol Rev, ; 38 (2): 143
Cell polarization in budding and fission yeasts.
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FEMS Microbiol Rev, ; 38 (2): 228-253
Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.
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Cell Cycle, ; 13 (4): 538-552

2013

Mate and fuse: how yeast cells do it.
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Open Biol, ; 3 (3): 130008
Cdc42 explores the cell periphery for mate selection in fission yeast.
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Curr Biol, ; 23 (1): 42-47

2012

Fission yeast: in shape to divide.
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Curr Opin Cell Biol, ; 24 (6): 858-864
Myosin Vs organize actin cables in fission yeast.
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Mol Biol Cell, ; 23 (23): 4579-4591
Being at the right place at the right time.
Mol Biol Cell, ; 23 (21): 4148-4150
Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles.
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PLoS One, ; 7 (6): e40248

2011

Shaping fission yeast cells by rerouting actin-based transport on microtubules.
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Curr Biol, ; 21 (24): 2064-2069
Deconstructing the cell cycle.
Nat Rev Mol Cell Biol, ; 12 (11): 689
A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.
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Cell, ; 145 (7): 1116-1128
Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.
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Mol Biol Cell, ; 22 (1): 44-53

2009

Geometric control of the cell cycle.
Cell Cycle, ; 8 (22): 3643-3647
Pob1 participates in the Cdc42 regulation of fission yeast actin cytoskeleton.
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Mol Biol Cell, ; 20 (20): 4390-4399
Microtubule-dependent cell morphogenesis in the fission yeast.
Trends Cell Biol, ; 19 (9): 447-454
Shaping fission yeast with microtubules.
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Cold Spring Harb Perspect Biol, ; 1 (1): a001347
Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.
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Nature, ; 459 (7248): 852-856
LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.
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Proc Natl Acad Sci U S A, ; 106 (22): 8941-8946

2007

Regulation of the formin for3p by cdc42p and bud6p.
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Mol Biol Cell, ; 18 (10): 4155-4167

2006

The cell-end factor pom1p inhibits mid1p in specification of the cell division plane in fission yeast.
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Curr Biol, ; 16 (24): 2480-2487
Dynamics of the formin for3p in actin cable assembly.
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Curr Biol, ; 16 (12): 1161-1170

2005

New end take off: regulating cell polarity during the fission yeast cell cycle.
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Cell Cycle, ; 4 (8): 1046-1049
Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.
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Dev Cell, ; 8 (4): 479-491
Regulation of actin assembly by microtubules in fission yeast cell polarity.
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Novartis Found Symp, ; 269 : 59-66; discussion 66-72, 223-30

2003

Cell polarity: a new mod(e) of anchoring.
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Curr Biol, ; 13 (18): R711-R713
The identification of novel genes required for Drosophila anteroposterior axis formation in a germline clone screen using GFP-Staufen.
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Development, ; 130 (17): 4201-4215
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.
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Nature, ; 421 (6921): 379-384

2001

Ku-deficient yeast strains exhibit alternative states of silencing competence.
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EMBO Rep, ; 2 (3): 203-210

2000

The dynamics of yeast telomeres and silencing proteins through the cell cycle.
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J Struct Biol, ; 129 (2-3): 159-174

1999

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.
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Cell, ; 97 (5): 621-633

1998

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.
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Curr Biol, ; 8 (11): 653-656
Targeting Sir proteins to sites of action: a general mechanism for regulated repression.
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Cold Spring Harb Symp Quant Biol, ; 63 : 401-412