Proteostasis and microtubule cytoskeleton

In our lab we challenge the central dogma postulating that regulation of gene expression and protein quantity is a unidirectional process. Our favourite proteins are tubulins—the main constituents of the microtubule cytoskeleton. We have recently shown how tubulin protein quantity feeds back into its encoding mRNA stability via a specificity factor. Our goal is to dissect the molecular mechanisms that govern tubulin protein quantity control using biochemical and structural approaches. To address the functional aspects of protein quantity control, we love fluorescent imaging of live and fixed mammalian cultured cells.

Link to ProMiCe Lab webpage

Funding