Uli K. Laemmli
Uli K. Laemmli was a Full Professor at the Department of Molecular, University of Geneva from 1980-2005.
1996 Louis-Jeantet Prize Winner
2008
The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes.
2006
Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide.
Nup-PI: the nucleopore-promoter interaction of genes in yeast.
2005
Chromosome structure: improved immunolabeling for electron microscopy.
2004
ChIC and ChEC; genomic mapping of chromatin proteins.
2003
A two-step scaffolding model for mitotic chromosome assembly.
Structural and dynamic functions establish chromatin domains.
2002
Chromatin boundaries in budding yeast: the nuclear pore connection.
Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains.
The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation.
2001
Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides.
2000
Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster.
Chromatin opening of DNA satellites by targeted sequence-specific drugs.
1999
Evidence for an antagonistic relationship between the boundary element-associated factor BEAF and the transcription factor DREF.
Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha.
1998
Identification of a class of chromatin boundary elements.
Facilitation of chromatin dynamics by SARs.
In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation.
1997
The scs' boundary element: characterization of boundary element-associated factors.
1996
A nuclear traffic jam: unraveling multicomponent machines and compartments.
Curr Opin Cell Biol,
1996 Jun;
8
(3): 299-302
A nuclear traffic jam - unraveling multicomponent machines and compartments.
Curr Opin Cell Biol,
1996 Jun 1;
8
(3): 299-302
1995
SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein.
Visualization of chromosomal domains with boundary element-associated factor BEAF-32.
1994
SARs stimulate but do not confer position independent gene expression.
Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts.
Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold.
1993
A simple method to renature DNA-binding proteins separated by SDS-polyacrylamide gel electrophoresis.
SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin.
A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin.
From the chromosomal loops and the scaffold to the classic bands of metaphase chromosomes.
1992
Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A.
Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains.
In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics.
1991
Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element.
Chromosome assembly in vitro: topoisomerase II is required for condensation.
1989
Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions.
Highly preferential nucleation of histone H1 assembly on scaffold-associated regions.
Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA).oligo(dT) tracts.
1988
The metaphase scaffold is helically folded: sister chromatids have predominantly opposite helical handedness.
Interaction of DNA with nuclear scaffolds in vitro.
Scaffold attachment of DNA loops in metaphase chromosomes.
1987
Relation of chromosome structure and gene expression.
Improved methods for the isolation of individual and clustered mitotic chromosomes.
1986
Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.
Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome.
Metaphase chromosome structure. Involvement of topoisomerase II.
The organisation of chromatin loops: characterization of a scaffold attachment site.
1984
Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins.
Mapping nucleolar proteins with monoclonal antibodies.
Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold.
Interphase nuclear matrix and metaphase scaffolding structures.
Silver staining the chromosome scaffold.
1983
Architecture of metaphase chromosomes and chromosome scaffolds.
1982
Higher order metaphase chromosome structure: evidence for metalloprotein interactions.
Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei.
Non-histone proteins and long-range organization of HeLa interphase DNA.
1980
Cell cycle changes in Physarum polycephalum histone H1 phosphate: relationship to deoxyribonucleic acid binding and chromosome condensation.
The detection of DNA-binding proteins by protein blotting.
1979
Metaphase chromosome structure: evidence for a radial loop model.
Maturation of the head of bacteriophage T4: 9-aminoacridine blocks a late step in DNA packaging.
1978
Levels of organization of the DNA in eucaryotic chromosomes.
Pharmacol Rev,
1978 Dec;
30
(4): 469-476
Metaphase chromosome structure: the role of nonhistone proteins.
1977
Isolation of a protein scaffold from mitotic HeLa cell chromosomes.
Role of nonhistone proteins in metaphase chromosome structure.
The structure of histone-depleted metaphase chromosomes.
Morphogenetic core of the bacteriophage T4 head. Structure of the core in polyheads.
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.
J Biol Chem,
1977 Feb 10;
252
(3): 1102-1106
1976
Studies on the maturation of the head of bacteriophage T4.
Head length determination in bacteriophage T4: the role of the core protein P22.
Correlation between structural transformation and cleavage of the major head protein of T4 bacteriophage.
1975
Characterization of DNA condensates induced by poly(ethylene oxide) and polylysine.
1974
Maturation of the head of bacteriophage T4. IV. The proteins of the core of the tubular polyheads and in vitro cleavage of the head proteins.
Maturation of the head of bacteriophage T4. III. DNA packaging into preformed heads.
Maturation of the head of bacteriophage T4. V. A possible DNA packaging mechanism: in vitro cleavage of the head proteins and the structure of the core of the polyhead.
1973
Maturation of the head of bacteriophage T4. II. Head-related, aberrant tau-particles.
Maturation of the head of bacteriophage T4. I. DNA packaging events.
Bacteriophage T4 tail assembly: structural proteins and their genetic identification.
1971
Polypeptides of the tail fibres of bacteriophage T4.
1970
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Form-determining function of the genes required for the assembly of the head of bacteriophage T4.
A factor preventing the major head protein of bacteriophage T4 from random aggregation.
1968
Studies on the morphopoiesis of the head of phage T-even. V. The formation of polyheads.