David Shore
David Shore was a Full Professor at the Department of Molecular Biology, University of Geneva from 1996-2020.
2024
K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment.
2023
K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ).
Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events.
2022
Ribosome biogenesis and the cellular energy economy.
2021
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals.
2020
Mechanisms coordinating ribosomal protein gene transcription in response to stress.
Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor.
Fork pausing complex engages topoisomerases at the replisome.
2019
Opposing chromatin remodelers control transcription initiation frequency and start site selection.
Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane.
A ribosome assembly stress response regulates transcription to maintain proteome homeostasis.
Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes.
2018
General Regulatory Factors Control the Fidelity of Transcription by Restricting Non-coding and Ectopic Initiation.
ChECing out Rif1 action in freely cycling cells.
Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genes.
Sequence-Directed Action of RSC Remodeler and General Regulatory Factors Modulates +1 Nucleosome Position to Facilitate Transcription.
Rif1 Binding and Control of Chromosome-Internal DNA Replication Origins Is Limited by Telomere Sequestration.
2017
Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Establishing nucleosome architecture and stability at promoters: Roles of pioneer transcription factors and the RSC chromatin remodeler.
A Reply to "MNase-Sensitive Complexes in Yeast: Nucleosomes and Non-histone Barriers," by Chereji et al.
TFIID or not TFIID, a continuing transcriptional SAGA.
2016
A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.
Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication.
Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.
Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in Yeasts.
2015
Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast.
2014
Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription.
Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.
2013
A chemostat array enables the spatio-temporal analysis of the yeast proteome.
Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1.
Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions.
2012
Massively parallel measurements of molecular interaction kinetics on a microfluidic platform.
The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae.
Anticheckpoint pathways at telomeres in yeast.
DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.
2011
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
2010
The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae.
2009
Growth control and ribosome biogenesis.
Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.
Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.
2008
Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.
How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.
Molecular biology. Refined view of the ends.
2007
Increased association of telomerase with short telomeres in yeast.
Early replication of short telomeres in budding yeast.
DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation.
2006
Fine-structure analysis of ribosomal protein gene transcription.
2005
Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing.
2004
Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1.
Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.
Distinct DNA elements contribute to Rap1p affinity for its binding sites.
Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.
2002
Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.
In vivo topography of Rap1p-DNA complex at Saccharomyces cerevisiae TEF2 UAS(RPG) during transcriptional regulation.
2001
Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast.
Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination.
Transcriptional silencing: replication redux.
A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae.
Telomeric chromatin: replicating and wrapping up chromosome ends.
2000
Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity.
The Sir2 protein family: A novel deacetylase for gene silencing and more.
Locus specificity determinants in the multifunctional yeast silencing protein Sir2.
1999
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.
Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.
1998
Telomeres--unsticky ends.
Cellular senescence: lessons from yeast for human aging?
1997
Telomerase and telomere-binding proteins: controlling the endgame.
Telomere length regulation: getting the measure of chromosome ends.
Biol Chem,
1997 Jul;
378
(7): 591-597
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.
Telomeres. Different means to common ends.
A protein-counting mechanism for telomere length regulation in yeast.
Genetic recombination: sex-change operations in yeast.
Rap1p and telomere length regulation in yeast.
1996
Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae.
SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability.
The means to bind the ends.
Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein.
Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence.
1995
Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.
Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.
Aging. Silence is golden.
Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.
Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.
1994
RAP1: a protean regulator in yeast.
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
1993
Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.
Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.
An essential yeast gene encoding a TTAGGG repeat-binding protein.
1992
A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.
Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing.
1991
Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.
RAP1 is required for BAS1/BAS2- and GCN4-dependent transcription of the yeast HIS4 gene.
RAP1 protein activates and silences transcription of mating-type genes in yeast.
1990
Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.
1987
Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements.
Transcriptional regulation in the yeast life cycle.
Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication.
1984
Characterization of two genes required for the position-effect control of yeast mating-type genes.