Steven A. Brown and the synchronization of circadian rhythms by body temperature cycles.

How the circadian nuclear orphan receptor REV-ERBα represses transcription: Temporal and spatial phase separation combined.

Steve Brown.

Recording of Diurnal Gene Expression in Peripheral Organs of Mice Using the RT-Biolumicorder.

PARP-1 drives slumber: A reciprocal relationship between sleep homeostasis and DNA damage repair.

BMAL1 dephosphorylation determines the pace of the circadian clock.

Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.

Senescence of Timing Reverted: NAD(+) Rejuvenates the Circadian Clock.

Oxidation of CLOCK boosts circadian rhythms.

Selenium cysteine and epileptic seizures.

Body clocks: Time for the Nobel Prize.

Mammalian Circadian Cogwheels Are Parts of Macromolecular Machines.

Getting Surprising Answers to Unasked Questions.

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.

Transcriptional regulatory logic of the diurnal cycle in the mouse liver.

Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock.

Posttranscriptional mechanisms controlling diurnal gene expression cycles by body temperature rhythms.

Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp.

Unbiased identification of signal-activated transcription factors by barcoded synthetic tandem repeat promoter screening (BC-STAR-PROM).

Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.

METABOLISM. A pancreatic clock times insulin release.

The systemic control of circadian gene expression.

Circadian timing of metabolism in animal models and humans.

Circadian rhythms - from genes to physiology and disease.

Glucocorticoid rhythm renders female mice more daring.

Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks.

Shedding new light on circadian clocks.

Body temperature cycles: gatekeepers of circadian clocks.

Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity.

The ticking tail: daily oscillations in mRNA poly(A) tail length drive circadian cycles in protein synthesis.

CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.

Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.

Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally.

REV-ERBs: more than the sum of the individual parts.

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators.

Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles.

Origins and consequences of transcriptional discontinuity.

Transcription factor loading: please take my place!

Mammalian genes are transcribed with widely different bursting kinetics.

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.

Crosstalk between components of circadian and metabolic cycles in mammals.

The mammalian circadian timing system: synchronization of peripheral clocks.

Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding.

Circadian cell-cycle progression: Cracking open the gate.

The mammalian circadian timing system: organization and coordination of central and peripheral clocks.

Physiology. Feeding the clock.

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

Integration of microRNA miR-122 in hepatic circadian gene expression.

The 2008 Pittendrigh/Aschoff lecture: peripheral phase coordination in the mammalian circadian timing system.

Circadian gene expression is resilient to large fluctuations in overall transcription rates.

Circadian glucose homeostasis requires compensatory interference between brain and liver clocks.

SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

In Vitro Screening for Regulated Transcription Factors with Differential Display of DNA-Binding Proteins (DDDP).

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor.

Physiology. Proteasomes keep the circadian clock ticking.

System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.

Circadian rhythms: mechanisms and therapeutic implications.

The daily timing of gene expression and physiology in mammals.

Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators.

Properties, entrainment, and physiological functions of mammalian peripheral oscillators.

A CLOCK-less clock.

[Circadian metabolism of medicaments: an important Geneva discovery].

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.

[The inter-individual variability of circadian period length in human skin cells].

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions.

Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms.

Circadian time keeping: the daily ups and downs of genes, cells, and organisms.

Enlightening the adrenal gland.

The period length of fibroblast circadian gene expression varies widely among human individuals.

The daily rhythms of genes, cells and organs. Biological clocks and circadian timing in cells.

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.

Cellular oscillators: rhythmic gene expression and metabolism.

Circadian gene expression in cultured cells.

Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells.

The mammalian circadian timing system: from gene expression to physiology.

The loss of circadian PAR bZip transcription factors results in epilepsy.

Circadian rhythms. Liver regeneration clocks on.

Peripheral circadian oscillators in mammals: time and food.

Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators.

A web of circadian pacemakers.

Rhythms of mammalian body temperature can sustain peripheral circadian clocks.

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.

Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.

Otto Naegeli Award 2002 honors the work of Prof. Walter Wahli.

Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators.

Circadian rhythms. Chronobiology--reducing time.

Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs.

Circadian regulation of gene expression in animals.

The Isolation of differentially expressed mRNA sequences by selective amplification via biotin and restriction-mediated enrichment.

Circadian rhythms: mop up the clock!

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts.

Resetting of circadian time in peripheral tissues by glucocorticoid signaling.

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.

Circadian clocks. Heartfelt enlightenment.

The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity.

Analysis of differential gene expression using the SABRE enrichment protocol.

The ins and outs of circadian timekeeping.

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

Molecular approaches towards the isolation of sleep-related genes.

An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor.

Circadian rhythms. New cogwheels in the clockworks.

A serum shock induces circadian gene expression in mammalian tissue culture cells.

The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior.

Selective amplification via biotin- and restriction-mediated enrichment (SABRE), a novel selective amplification procedure for detection of differentially expressed mRNAs.

Developmental testis-specific regulation of mRNA levels and mRNA translational efficiencies for TATA-binding protein mRNA isoforms.

Spermatid-specific overexpression of the TATA-binding protein gene involves recruitment of two potent testis-specific promoters.

Biology: an expanding universe--or is convergence to a few principles around the corner?

DNA-binding specificity of PAR and C/EBP leucine zipper proteins: a single amino acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP.

The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences.

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation.

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

High accumulation of components of the RNA polymerase II transcription machinery in rodent spermatids.

Cell size regulation, a mechanism that controls cellular RNA accumulation: consequences on regulation of the ubiquitous transcription factors Oct1 and NF-Y and the liver-enriched transcription factor DBP.

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

The 5' flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic mice.

A simple method to renature DNA-binding proteins separated by SDS-polyacrylamide gel electrophoresis.

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

The role of the transcriptional activator protein DBP in circadian liver gene expression.

Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA.

How are the regulators regulated?

Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm.

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

A ubiquitous CCAAT factor is required for efficient in vitro transcription from the mouse albumin promoter.

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally.

Differential in vitro transcription from the promoter of a rat alpha 2u globulin gene in liver and spleen nuclear extracts.

Rapid identification of DNA fragments containing promoters for RNA polymerase II.

A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene.

Metastatic hibernomas in transgenic mice expressing an alpha-amylase-SV40 T antigen hybrid gene.

The role of cis-acting promoter elements in tissue-specific albumin gene expression.

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.

Alternative promoters in developmental gene expression.

Structure and expression of the parotid secretory protein gene of mouse.

Tissue-specific in vitro transcription from the mouse albumin promoter.

Different tissue-specific expression of the amylase gene Amy-1 in mice and rats.

Developmental coordination of alpha-amylase and psp gene expression during mouse parotid gland differentiation is controlled posttranscriptionally.

Structural arrangement and tissue-specific expression of the two murine alpha-amylase loci Amy-1 and Amy-2.

Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters.

Mouse alpha-amylase loci, Amy-1a and Amy-2a, are closely linked.

The two promoters of the mouse alpha-amylase gene Amy-1a are differentially activated during parotid gland differentiation.

Accumulation of rare and moderately abundant mRNAs in mouse L-cells is mainly post-transcriptionally regulated.

Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site.

Rapid size determination of mRNAs complementary to cloned DNA sequences: plaque and colony hybrid-selection of cDNAs.

Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver.

The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver.

Tissue specific expression of mouse alpha-amylase genes.

Multiple polyadenylation sites in a mouse alpha-amylase gene.

Mouse beta-globin and adenovirus-2 major late transcripts are initiated at the cap site in vitro.

Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences.

A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs.

Tissue-specific expression of mouse alpha-amylase genes.

Comparison of mRNA precursors in plasmacytomas producing closely related kappa chains.

Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences.

Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells.

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells.

The 5'-terminal sequences of immunoglobulin messenger RNAs of a mouse myeloma.

The 5'-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages.

Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells.