Publications
2025
Rapid and sensitive protein complex alignment with Foldseek-Multimer.
Structural determinants of co-translational protein complex assembly.
2024
Mutational biases favor complexity increases in protein interaction networks after gene duplication.
An atlas of protein homo-oligomerization across domains of life.
2023
CC(+) : A searchable database of validated coiled coils in PDB structures and AlphaFold2 models.
Mesoscale molecular assembly is favored by the active, crowded cytoplasm.
Discriminating physiological from non-physiological interfaces in structures of protein complexes: A community-wide study.
2022
Molecular and environmental determinants of biomolecular condensate formation.
How gene duplication diversifies the landscape of protein oligomeric state and function.
Affinity and Valence Impact the Extent and Symmetry of Phase Separation of Multivalent Proteins.
A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates.
Synthetic condensate size correlates with yeast replicative cell age.
The modular cell gets connected.
Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells.
PDBe-KB: collaboratively defining the biological context of structural data.
QSalignWeb: A Server to Predict and Analyze Protein Quaternary Structure.
2021
PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry.
Altered Protein Abundance and Localization Inferred from Sites of Alternative Modification by Ubiquitin and SUMO.
Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins.
"Structuromics": another step toward a holistic view of the cell.
2020
Not Going with the Flow: How Cells Adapt Internal Physics.
Designer protein assemblies with tunable phase diagrams in living cells.
Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.
PDBe-KB: a community-driven resource for structural and functional annotations.
2019
Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions.
Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast.
Geometric description of self-interaction potential in symmetric protein complexes.
Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering.
Evolthon: A community endeavor to evolve lab evolution.
YeastRGB: comparing the abundance and localization of yeast proteins across cells and libraries.
2018
Genome-wide C-SWAT library for high-throughput yeast genome tagging.
Genome-wide SWAp-Tag yeast libraries for proteome exploration.
PDB-wide identification of biological assemblies from conserved quaternary structure geometry.
Inferring and Using Protein Quaternary Structure Information from Crystallographic Data.
2017
Proteins evolve on the edge of supramolecular self-assembly.
Exhaustive search of linear information encoding protein-peptide recognition.
2016
The Dihydrofolate Reductase Protein-Fragment Complementation Assay: A Survival-Selection Assay for Large-Scale Analysis of Protein-Protein Interactions.
Protein-Fragment Complementation Assays for Large-Scale Analysis, Functional Dissection, and Spatiotemporal Dynamic Studies of Protein-Protein Interactions in Living Cells.
Young phosphorylation is functionally silent.
Evolution of domain-peptide interactions to coadapt specificity and affinity to functional diversity.
2015
Decoding a neural circuit controlling global animal state in C. elegans.
Symmetry breaking in homo-oligomers: the curious case of mega-hemocyanin.
2014
Fast and accurate discovery of degenerate linear motifs in protein sequences.
Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties.
High-resolution mapping of protein concentration reveals principles of proteome architecture and adaptation.
2013
Extracting insight from noisy cellular networks.
Structural, evolutionary, and assembly principles of protein oligomerization.
2012
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.
2010
A simple definition of structural regions in proteins and its use in analyzing interface evolution.
Molecular characterization of the evolution of phagosomes.
Homomeric protein complexes: evolution and assembly.
Systemizing the structures and structuring the system.
Cell signaling. Signaling through cooperation.
2009
Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins.
Weak functional constraints on phosphoproteomes.
Self-assembly and evolution of homomeric protein complexes.
How perfect can protein interactomes be?
2008
Assembly reflects evolution of protein complexes.
Evolution and dynamics of protein interactions and networks.
2007
PiQSi: protein quaternary structure investigation.
CORRIE: enzyme sequence annotation with confidence estimates.
Evolution of protein complexes by duplication of homomeric interactions.
2006
3D complex: a structural classification of protein complexes.
The origins and evolution of functional modules: lessons from protein complexes.
2005
Probabilistic annotation of protein sequences based on functional classifications.