Publications
2024
Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
J Cell Sci,2024 Mar 1137(5):
DOI: 10.1242/jcs.260745
2023
Knock Out of CGN and CGNL1 in MDCK Cells Affects Claudin-2 but Has a Minor Impact on Tight Junction Barrier Function.
Cells,2023 Aug 512(15):
Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane.
J Cell Biol,2023 Jul 3222(7):
2022
The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.
J Biol Chem,2022 Aug298(8):
Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation.
J Biol Chem,2022 Apr298(4):
The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell-Cell Junctions of Epithelial Cells.
Cells,2022 Feb 1111(4):
2021
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.
Mol Biol Cell,2021 Nov 132(21):
WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7.
Front Cell Dev Biol,20219:
2020
The tight junction protein cingulin regulates the vascular response to burn injury in a mouse model.
Microvasc Res,2020 Nov132:
Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics.
Biochim Biophys Acta Biomembr,2020 Oct 11862(10):
Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
J Biol Chem,2020 Jul 10295(28):
Cell Biology: Tight Junctions as Biomolecular Condensates.
Curr Biol,2020 Jan 2030(2):
2019
The mechanobiology of tight junctions.
Biophys Rev,2019 Oct11(5):
R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing.
Tissue Barriers,20197(3):
2018
A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity.
Cell Rep,2018 Nov 2025(8):
Intestinal barriers protect against disease.
Science,2018 Mar 9359(6380):
The role of microtubules in the regulation of epithelial junctions.
Tissue Barriers,20186(3):
2017
Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors.
Curr Biol,2017 Dec 1827(24):
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Ann N Y Acad Sci,2017 Oct1405(1):
DOI: 10.1111/nyas.13391
The role of apical cell-cell junctions and associated cytoskeleton in mechanotransduction.
Biol Cell,2017 Apr109(4):
2016
Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.
J Biol Chem,2016 Nov 4291(45):
Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells.
Nat Commun,2016 Aug 37:
DOI: 10.1038/ncomms12426
PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling.
Int J Biochem Cell Biol,2016 Jun75:
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
J Biol Chem,2016 May 20291(21):
Grete Kellenberger-Gujer: Molecular biology research pioneer.
Bacteriophage,2016 Apr-Jun6(2):
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Arterioscler Thromb Vasc Biol,2016 Apr36(4):
2015
The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.
Proc Natl Acad Sci U S A,2015 Nov 17112(46):
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Nat Cell Biol,2015 Sep17(9):
DOI: 10.1038/ncb3227
The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas.
PLoS One,201510(8):
2014
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
J Biol Chem,2014 Aug 8289(32):
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
Mol Biol Cell,2014 Jul 125(13):
Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1.
Tissue Barriers,20142:
DOI: 10.4161/tisb.29166
Epithelial junctions and Rho family GTPases: the zonular signalosome.
Small GTPases,20145(4):
PLEKHA7 modulates epithelial tight junction barrier function.
Tissue Barriers,2014 Jan 12(1):
DOI: 10.4161/tisb.28755
2013
The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4.
PLoS One,20138(2):
2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
J Cell Sci,2012 Nov 1125(Pt 21):
DOI: 10.1242/jcs.101261
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex.
Ann N Y Acad Sci,2012 Jun1257:
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
J Biol Chem,2012 Apr 13287(16):
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
Essays Biochem,201253:
DOI: 10.1042/bse0530083
2011
Regulation of small GTPases at epithelial cell-cell junctions.
Mol Membr Biol,2011 Oct-Nov28(7-8):
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
J Biol Chem,2011 May 13286(19):
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
Mol Membr Biol,2011 Feb28(2):
2010
PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin.
PLoS One,2010 Aug 205(8):
2009
The tight junction protein cingulin regulates gene expression and RhoA signaling.
Ann N Y Acad Sci,2009 May1165:
2008
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
Mol Biol Cell,2008 Oct19(10):
The cytoplasmic plaque of tight junctions: a scaffolding and signalling center.
Biochim Biophys Acta,2008 Mar1778(3):
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Mol Membr Biol,2008 Jan25(1):
2007
Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles.
Cell Tissue Res,2007 Nov330(2):
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Mod Pathol,2007 Sep20(9):
2006
Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
Mol Biol Cell,2006 Aug17(8):
2005
Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.
Dev Cell,2005 May8(5):
2004
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Mol Cancer Res,2004 Dec2(12):
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
J Cell Sci,2004 Oct 15117(Pt 22):
DOI: 10.1242/jcs.01399
2003
What's new in tight junctions: a report on the 2002 ASCB Meeting, San Francisco, CA.
Cell Commun Adhes,2003 Jan-Feb10(1):
2002
Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.
J Biol Chem,2002 Aug 2277(31):
Molecular complexity of vertebrate tight junctions (Review).
Mol Membr Biol,2002 Apr-Jun19(2):
2001
Cingulin interacts with F-actin in vitro.
FEBS Lett,2001 Oct 19507(1):
2000
Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.
Mech Dev,2000 Oct97(1-2):
Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.
J Struct Biol,2000 Aug131(2):
Introduction: opening up tight junctions
Semin Cell Dev Biol,2000 Aug11(4):
Tight junction biogenesis in the early Xenopus embryo.
Mech Dev,2000 Aug96(1):
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin.
J Biol Chem,2000 Jul 7275(27):
1999
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
J Cell Biol,1999 Dec 27147(7):
Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin.
Eur J Biochem,1999 Sep264(2):
Experimental colitis increases small intestine permeability in the rat.
Lab Invest,1999 Jan79(1):
1998
Tight junction proteins.
Biochim Biophys Acta,1998 Nov 191448(1):
1997
Hepatocyte tight-junctional permeability is increased in rat experimental colitis.
Gastroenterology,1997 Oct113(4):
1996
Tight junctions in early amphibian development: detection of junctional cingulin from the 2-cell stage and its localization at the boundary of distinct membrane domains in dividing blastomeres in low calcium.
Dev Dyn,1996 Sep207(1):
DOI: 10.1002/(SICI)1097-0177(199609)207:1<104::AID-AJA10>3.0.CO;2-0
1995
Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties.
Circulation,1995 Dec 192(11):
1994
Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.
Cell Motil Cytoskeleton,199429(4):
DOI: 10.1002/cm.970290405
1993
The molecular organization of tight junctions.
J Cell Biol,1993 May121(3):
Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development.
Development,1993 Mar117(3):
Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development.
Development,1993 Mar117(3):
1992
Polarized functions and permeability properties of rat epididymal epithelial cells in vitro.
J Reprod Fertil,1992 Jul95(2):
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
J Cell Biol,1992 Apr117(1):
1991
The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells.
Biochem Biophys Res Commun,1991 Dec 16181(2):
Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.
Am J Pathol,1991 Apr138(4):
Localization of myosin in the cytoskeleton of brush border cells using monoclonal antibodies and confocal laser-beam scanning microscopy.
Tissue Cell,199123(6):
1989
ZO-1 and cingulin: tight junction proteins with distinct identities and localizations.
Am J Physiol,1989 Oct257(4 Pt 1):
Parallel modulation of brush border myosin conformation and enzyme activity induced by monoclonal antibodies.
J Cell Biol,1989 Aug109(2):
Cingulin: characterization and localization.
J Cell Sci,1989 May93 ( Pt 1):
DOI: 10.1242/jcs.93.1.107
1988
Modulation of cellular morphology and locomotory activity by antibodies against myosin.
J Cell Biol,1988 Dec107(6 Pt 1):
Active site trapping of nucleotide by smooth and non-muscle myosins.
J Mol Biol,1988 Sep 5203(1):
How phosphorylation controls the self-assembly of vertebrate smooth and non-muscle myosins.
Biochem Soc Trans,1988 Aug16(4):
DOI: 10.1042/bst0160501
Brush border myosin filament assembly and interaction with actin investigated with monoclonal antibodies.
J Muscle Res Cell Motil,1988 Aug9(4):
DOI: 10.1007/BF01773874
Cingulin, a new peripheral component of tight junctions.
Nature,1988 May 19333(6170):
DOI: 10.1038/333272a0
1987
Effects of light chain phosphorylation and skeletal myosin on the stability of non-muscle myosin filaments.
J Mol Biol,1987 Nov 20198(2):
Polymerization of vertebrate non-muscle and smooth muscle myosins.
J Mol Biol,1987 Nov 20198(2):
Regulation of non-muscle myosin structure and function.
Bioessays,1987 Oct7(4):
Studies on the structure and conformation of brush border myosin using monoclonal antibodies.
Eur J Biochem,1987 Jun 1165(2):
1986
Regulation in vitro of brush border myosin by light chain phosphorylation.
J Mol Biol,1986 Apr 5188(3):