Sandra Citi

Publications

2025

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics.
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Nat Commun, ; 16 (1): 2514

2024

Evidence for an interaction of paracingulin with microtubules.
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MicroPubl Biol, ; 2024
Cingulin-nonmuscle myosin interaction plays a role in epithelial morphogenesis and cingulin nanoscale organization.
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J Cell Sci, ; 137 (18)
A short guide to the tight junction.
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J Cell Sci, ; 137 (9)

2023

Knock Out of CGN and CGNL1 in MDCK Cells Affects Claudin-2 but Has a Minor Impact on Tight Junction Barrier Function.
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Cells, ; 12 (15)
Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane.
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J Cell Biol, ; 222 (7)
Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
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J Cell Sci, ; 137 (5)

2022

The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.
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J Biol Chem, ; 298 (8): 102138
Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation.
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J Biol Chem, ; 298 (4): 101797
The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell-Cell Junctions of Epithelial Cells.
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Cells, ; 11 (4)

2021

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.
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Mol Biol Cell, ; 32 (21): ar34
WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7.
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Front Cell Dev Biol, ; 9 : 729444

2020

The tight junction protein cingulin regulates the vascular response to burn injury in a mouse model.
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Microvasc Res, ; 132 : 104067
Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics.
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Biochim Biophys Acta Biomembr, ; 1862 (10): 183399
Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
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J Biol Chem, ; 295 (28): 9299-9312
Cell Biology: Tight Junctions as Biomolecular Condensates.
Curr Biol, ; 30 (2): R83-R86

2019

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β.
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Nat Commun, ; 10 (1): 1969
R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing.
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Tissue Barriers, ; 7 (3): e1653748

2018

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity.
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Cell Rep, ; 25 (8): 2132-2147.e7
Intestinal barriers protect against disease.
Science, ; 359 (6380): 1097-1098
The role of microtubules in the regulation of epithelial junctions.
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Tissue Barriers, ; 6 (3): 1539596

2017

Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors.
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Curr Biol, ; 27 (24): 3783-3795.e8
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
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Ann N Y Acad Sci, ; 1405 (1): 160-176
The role of apical cell-cell junctions and associated cytoskeleton in mechanotransduction.
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Biol Cell, ; 109 (4): 139-161

2016

Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.
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J Biol Chem, ; 291 (45): 23681-23692
Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells.
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Nat Commun, ; 7 : 12426
PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling.
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Int J Biochem Cell Biol, ; 75 : 112-116
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
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J Biol Chem, ; 291 (21): 11016-11029
Grete Kellenberger-Gujer: Molecular biology research pioneer.
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Bacteriophage, ; 6 (2): e1148805
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
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Arterioscler Thromb Vasc Biol, ; 36 (4): 647-654

2015

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.
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Proc Natl Acad Sci U S A, ; 112 (46): 14337-14342
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
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Nat Cell Biol, ; 17 (9): 1145-1157
The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas.
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PLoS One, ; 10 (8): e0135442

2014

ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
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J Biol Chem, ; 289 (32): 22500-22511
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
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Mol Biol Cell, ; 25 (13): 1995-2005
Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1.
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Tissue Barriers, ; 2 : e29166
PLEKHA7 modulates epithelial tight junction barrier function.
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Tissue Barriers, ; 2 (1): e28755
Epithelial junctions and Rho family GTPases: the zonular signalosome.
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Small GTPases, ; 5 (4): 1-15

2013

The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4.
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PLoS One, ; 8 (2): e55873

2012

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
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J Cell Sci, ; 125 (Pt 21): 5005-5014
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex.
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Ann N Y Acad Sci, ; 1257 : 125-132
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
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J Biol Chem, ; 287 (16): 13159-13169
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
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Essays Biochem, ; 53 : 83-93

2011

Regulation of small GTPases at epithelial cell-cell junctions.
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Mol Membr Biol, ; 28 (7-8): 427-444
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
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J Biol Chem, ; 286 (19): 16743-16750
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
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Mol Membr Biol, ; 28 (2): 123-135

2010

PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin.
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PLoS One, ; 5 (8): e12207

2009

The tight junction protein cingulin regulates gene expression and RhoA signaling.
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Ann N Y Acad Sci, ; 1165 : 88-98

2008

Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
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Mol Biol Cell, ; 19 (10): 4442-4453
The cytoplasmic plaque of tight junctions: a scaffolding and signalling center.
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Biochim Biophys Acta, ; 1778 (3): 601-613
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
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Mol Membr Biol, ; 25 (1): 1-13

2007

Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles.
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Cell Tissue Res, ; 330 (2): 247-256
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
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Mod Pathol, ; 20 (9): 947-954

2006

Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
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Mol Biol Cell, ; 17 (8): 3569-3577

2005

Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.
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Dev Cell, ; 8 (5): 777-786

2004

Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
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Mol Cancer Res, ; 2 (12): 692-701
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
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J Cell Sci, ; 117 (Pt 22): 5245-5256

2003

What's new in tight junctions: a report on the 2002 ASCB Meeting, San Francisco, CA.
Cell Commun Adhes, ; 10 (1): 51-54

2002

Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.
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J Biol Chem, ; 277 (31): 27757-27764
Molecular complexity of vertebrate tight junctions (Review).
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Mol Membr Biol, ; 19 (2): 103-112

2001

2000

Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.
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Mech Dev, ; 97 (1-2): 93-104
Tight junction biogenesis in the early Xenopus embryo.
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Mech Dev, ; 96 (1): 51-65
Introduction: opening up tight junctions.
Semin Cell Dev Biol, ; 11 (4): 277-279
Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.
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J Struct Biol, ; 131 (2): 135-145
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin.
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J Biol Chem, ; 275 (27): 20520-20526

1999

Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
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J Cell Biol, ; 147 (7): 1569-1582
Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin.
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Eur J Biochem, ; 264 (2): 374-384
Experimental colitis increases small intestine permeability in the rat.
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Lab Invest, ; 79 (1): 49-57

1998

1997

Hepatocyte tight-junctional permeability is increased in rat experimental colitis.
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Gastroenterology, ; 113 (4): 1347-1354

1996

Tight junctions in early amphibian development: detection of junctional cingulin from the 2-cell stage and its localization at the boundary of distinct membrane domains in dividing blastomeres in low calcium.
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Dev Dyn, ; 207 (1): 104-113

1995

Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties.
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Circulation, ; 92 (11): 3289-3296

1994

Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.
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Cell Motil Cytoskeleton, ; 29 (4): 321-338

1993

The molecular organization of tight junctions.
J Cell Biol, ; 121 (3): 485-489
Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development.
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Development, ; 117 (3): 1135-1144
Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development.
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Development, ; 117 (3): 1145-1151

1992

Polarized functions and permeability properties of rat epididymal epithelial cells in vitro.
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J Reprod Fertil, ; 95 (2): 385-396
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
J Cell Biol, ; 117 (1): 169-178

1991

The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells.
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Biochem Biophys Res Commun, ; 181 (2): 548-553
Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.
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Am J Pathol, ; 138 (4): 781-789
Localization of myosin in the cytoskeleton of brush border cells using monoclonal antibodies and confocal laser-beam scanning microscopy.
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Tissue Cell, ; 23 (6): 789-799

1989

ZO-1 and cingulin: tight junction proteins with distinct identities and localizations.
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Am J Physiol, ; 257 (4 Pt 1): C621-C628
Parallel modulation of brush border myosin conformation and enzyme activity induced by monoclonal antibodies.
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J Cell Biol, ; 109 (2): 549-556
Cingulin: characterization and localization.
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J Cell Sci, ; 93 ( Pt 1) : 107-122

1988

Modulation of cellular morphology and locomotory activity by antibodies against myosin.
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J Cell Biol, ; 107 (6 Pt 1): 2181-2189
Active site trapping of nucleotide by smooth and non-muscle myosins.
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J Mol Biol, ; 203 (1): 173-181
Brush border myosin filament assembly and interaction with actin investigated with monoclonal antibodies.
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J Muscle Res Cell Motil, ; 9 (4): 306-319
How phosphorylation controls the self-assembly of vertebrate smooth and non-muscle myosins.
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Biochem Soc Trans, ; 16 (4): 501-503
Cingulin, a new peripheral component of tight junctions.
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Nature, ; 333 (6170): 272-276

1987

Effects of light chain phosphorylation and skeletal myosin on the stability of non-muscle myosin filaments.
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J Mol Biol, ; 198 (2): 253-262
Polymerization of vertebrate non-muscle and smooth muscle myosins.
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J Mol Biol, ; 198 (2): 241-252
Regulation of non-muscle myosin structure and function.
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Bioessays, ; 7 (4): 155-159
Studies on the structure and conformation of brush border myosin using monoclonal antibodies.
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Eur J Biochem, ; 165 (2): 315-325

1986

Regulation in vitro of brush border myosin by light chain phosphorylation.
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J Mol Biol, ; 188 (3): 369-382