Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane.
J Cell Biol,2023 Jul 3222(7):
Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
J Cell Sci,2024 Mar 1137(5):
The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.
J Biol Chem,2022 Aug298(8):
Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation.
J Biol Chem,2022 Apr298(4):
The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell-Cell Junctions of Epithelial Cells.
Cells,2022 Feb 1111(4):
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.
Mol Biol Cell,2021 Nov 132(21):
WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7.
Front Cell Dev Biol,20219:
The tight junction protein cingulin regulates the vascular response to burn injury in a mouse model.
Microvasc Res,2020 Nov132:
Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics.
Biochim Biophys Acta Biomembr,2020 Oct 11862(10):
Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
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Cell Biology: Tight Junctions as Biomolecular Condensates.
Curr Biol,2020 Jan 2030(2):
The mechanobiology of tight junctions.
Biophys Rev,2019 Oct11(5):
R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing.
A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity.
Cell Rep,2018 Nov 2025(8):
Intestinal barriers protect against disease.
Science,2018 Mar 9359(6380):
The role of microtubules in the regulation of epithelial junctions.
Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors.
Curr Biol,2017 Dec 1827(24):
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Ann N Y Acad Sci,2017 Oct1405(1):
The role of apical cell-cell junctions and associated cytoskeleton in mechanotransduction.
Biol Cell,2017 Apr109(4):
Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.
J Biol Chem,2016 Nov 4291(45):
Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells.
Nat Commun,2016 Aug 37:
PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling.
Int J Biochem Cell Biol,2016 Jun75:
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
J Biol Chem,2016 May 20291(21):
Grete Kellenberger-Gujer: Molecular biology research pioneer.
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Arterioscler Thromb Vasc Biol,2016 Apr36(4):
The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.
Proc Natl Acad Sci U S A,2015 Nov 17112(46):
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Nat Cell Biol,2015 Sep17(9):
The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas.
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
J Biol Chem,2014 Aug 8289(32):
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
Mol Biol Cell,2014 Jul 125(13):
Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1.
Epithelial junctions and Rho family GTPases: the zonular signalosome.
PLEKHA7 modulates epithelial tight junction barrier function.
Tissue Barriers,2014 Jan 12(1):
The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4.
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
J Cell Sci,2012 Nov 1125(Pt 21):
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex.
Ann N Y Acad Sci,2012 Jun1257:
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
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The control of gene expression and cell proliferation by the epithelial apical junctional complex.
Regulation of small GTPases at epithelial cell-cell junctions.
Mol Membr Biol,2011 Oct-Nov28(7-8):
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
J Biol Chem,2011 May 13286(19):
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
Mol Membr Biol,2011 Feb28(2):
PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin.
PLoS One,2010 Aug 205(8):
The tight junction protein cingulin regulates gene expression and RhoA signaling.
Ann N Y Acad Sci,2009 May1165:
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
Mol Biol Cell,2008 Oct19(10):
The cytoplasmic plaque of tight junctions: a scaffolding and signalling center.
Biochim Biophys Acta,2008 Mar1778(3):
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Mol Membr Biol,2008 Jan25(1):
Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles.
Cell Tissue Res,2007 Nov330(2):
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Mod Pathol,2007 Sep20(9):
Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
Mol Biol Cell,2006 Aug17(8):
Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.
Dev Cell,2005 May8(5):
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Mol Cancer Res,2004 Dec2(12):
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
J Cell Sci,2004 Oct 15117(Pt 22):
What's new in tight junctions: a report on the 2002 ASCB Meeting, San Francisco, CA.
Cell Commun Adhes,2003 Jan-Feb10(1):
Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.
J Biol Chem,2002 Aug 2277(31):
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Mol Membr Biol,2002 Apr-Jun19(2):
Cingulin interacts with F-actin in vitro.
FEBS Lett,2001 Oct 19507(1):
Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.
Mech Dev,2000 Oct97(1-2):
Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.
J Struct Biol,2000 Aug131(2):
Introduction: opening up tight junctions
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Mech Dev,2000 Aug96(1):
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin.
J Biol Chem,2000 Jul 7275(27):
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
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Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development.
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J Reprod Fertil,1992 Jul95(2):
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
J Cell Biol,1992 Apr117(1):
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Biochem Biophys Res Commun,1991 Dec 16181(2):
Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.
Am J Pathol,1991 Apr138(4):
Localization of myosin in the cytoskeleton of brush border cells using monoclonal antibodies and confocal laser-beam scanning microscopy.
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J Cell Biol,1989 Aug109(2):
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J Cell Biol,1988 Dec107(6 Pt 1):
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J Muscle Res Cell Motil,1988 Aug9(4):
Cingulin, a new peripheral component of tight junctions.
Nature,1988 May 19333(6170):
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J Mol Biol,1987 Nov 20198(2):
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J Mol Biol,1987 Nov 20198(2):
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Eur J Biochem,1987 Jun 1165(2):
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