Signaling by cell-cell junctions
The goal of our research is to understand the molecular mechanisms (control of Rho GTPases, transcription factors, transmembrane receptors, mechanodependent protein conformation, etc) through which cell-cell junctions regulate signaling, to control cytoskeletal organization, morphogenesis, proliferation, and many other aspects of cell behavior related to the physiology and pathology of tissues and organs. Junctions are particularly important in epithelial and endothelial cells, for cell adhesion, barrier function, communication, and control or organ growth and physiology. Epithelial and endothelial cells are also implicated in major diseases. Our laboratory uses many methodological approaches, including biochemistry, cell culture, and mouse models.
Sandra CITI, MD, PhD