Publications

2024

S100A9 exerts insulin-independent antidiabetic and anti-inflammatory effects.

Ursino G, Lucibello G, Teixeira PDS, Höfler A, Veyrat-Durebex C, Odouard S, Visentin F, Galgano L, Somm E, Vianna CR, Widmer A, Jornayvaz FR, Boland A, Ramadori G, Coppari R

Sci Adv,2024 Jan 510(1):

DOI: 10.1126/sciadv.adj4686

2023

Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist.

Yu J, Kumar A, Zhang X, Martin C, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M

bioRxiv,2023 Dec 7:

DOI: 10.1101/2023.12.06.570395

The molecular mechanisms of human separase regulation.

Yu J, Morgan DO, Boland A

Biochem Soc Trans,2023 Jun 2851(3):

DOI: 10.1042/BST20221400

2022

Structural biology of DOCK-family guanine nucleotide exchange factors.

Boland A, Côté JF, Barford D

FEBS Lett,2023 Mar597(6):

DOI: 10.1002/1873-3468.14523

CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.

Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M

FEBS J,2022 Aug 23:

DOI: 10.1111/febs.16600

Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.

Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PDS, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R

Nat Commun,2022 Jul 1513(1):

DOI: 10.1038/s41467-022-31803-5

2021

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.

Raia P, Yu J, Boland A

Mol Cell Oncol,20218(4):

DOI: 10.1080/23723556.2021.1975473

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

Heimhalt M, Berndt A, Wagstaff J, Anandapadamanaban M, Perisic O, Maslen S, McLaughlin S, Yu CW, Masson GR, Boland A, Ni X, Yamashita K, Murshudov GN, Skehel M, Freund SM, Williams RL

Elife,2021 Sep 1410:

DOI: 10.7554/eLife.68799

Structural basis of human separase regulation by securin and CDK1-cyclin B1.

Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A

Nature,2021 Aug596(7870):

DOI: 10.1038/s41586-021-03764-0

2020

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.

Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith MJ, Côté JF, Barford D

Nat Commun,2020 Jul 1011(1):

DOI: 10.1038/s41467-020-17271-9

2019

A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.

Kiss L, Zeng J, Dickson CF, Mallery DL, Yang JC, McLaughlin SH, Boland A, Neuhaus D, James LC

Nat Commun,2019 Oct 310(1):

DOI: 10.1038/s41467-019-12388-y

2018

The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1.

Sosnowski P, Urnavicius L, Boland A, Fagiewicz R, Busselez J, Papai G, Schmidt H

Elife,2018 Nov 267:

DOI: 10.7554/eLife.39163

2017

The potential of cryo-electron microscopy for structure-based drug design.

Boland A, Chang L, Barford D

Essays Biochem,2017 Nov 861(5):

DOI: 10.1042/EBC20170032

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Boland A, Martin TG, Zhang Z, Yang J, Bai XC, Chang L, Scheres SH, Barford D

Nat Struct Mol Biol,2017 Apr24(4):

DOI: 10.1038/nsmb.3386

2015

Fast native-SAD phasing for routine macromolecular structure determination.

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wan

Nat Methods,2015 Feb12(2):

DOI: 10.1038/nmeth.3211

2014

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.

Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E

Mol Cell,2014 Jun 554(5):

DOI: 10.1016/j.molcel.2014.03.034

2013

Structure and assembly of the NOT module of the human CCR4-NOT complex.

Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E

Nat Struct Mol Biol,2013 Nov20(11):

DOI: 10.1038/nsmb.2681

Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.

Christie M, Boland A, Huntzinger E, Weichenrieder O, Izaurralde E

Mol Cell,2013 Aug 851(3):

DOI: 10.1016/j.molcel.2013.07.011

2012

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.

Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E

Nat Struct Mol Biol,2012 Dec19(12):

DOI: 10.1038/nsmb.2413

2011

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein.

Boland A, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O

Proc Natl Acad Sci U S A,2011 Jun 28108(26):

DOI: 10.1073/pnas.1103946108

2010

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein.

Boland A, Tritschler F, Heimstädt S, Izaurralde E, Weichenrieder O

EMBO Rep,2010 Jul11(7):

DOI: 10.1038/embor.2010.81

Andreas Boland