Publications
2024
Transcription-replication conflicts underlie sensitivity to PARP inhibitors.
Nature,2024 Mar 20:
Homozygous substitution of threonine 191 by proline in polymerase η causes Xeroderma pigmentosum variant.
Sci Rep,2024 Jan 1114(1):
2023
High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells.
STAR Protoc,2023 Mar 174(1):
2022
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.
Mol Cell,2022 Sep 1582(18):
RAD51 protects human cells from transcription-replication conflicts.
Mol Cell,2022 Sep 1582(18):
Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits.
Sci Rep,2022 Feb 1512(1):
Beating cancer one carbon at a time.
Nat Cancer,2022 Feb3(2):
2021
Delayed DNA break repair for genome stability.
Nat Cell Biol,2021 Oct23(10):
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells.
Nat Commun,2021 Aug 1312(1):
Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes.
Cancers (Basel),2021 Mar 1213(6):
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening.
iScience,2021 Feb 1924(2):
A method to sequence genomic sites of mitotic DNA synthesis in mammalian cells.
Methods Enzymol,2021661:
2020
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.
Cell Res,2020 Nov30(11):
Draining the FEN1s for cancer therapy.
Proc Natl Acad Sci U S A,2020 Sep 8117(36):
2019
Remodeling Collapsed DNA Replication Forks for Cancer Development.
Cancer Res,2019 Apr 179(7):
Monitoring early S-phase origin firing and replication fork movement by sequencing nascent DNA from synchronized cells.
Nat Protoc,2019 Jan14(1):
Monitoring early S-phase origin firing and replication fork movement by sequencing nascent DNA from synchronized cells.
Nat Protoc,2019 Jan14(1):
2018
Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
Nature,2018 Mar 1555(7694):
DOI: 10.1038/nature25507
2017
Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue.
Cell Rep,2017 Jun 1319(11):
The role of SMARCAL1 in replication fork stability and telomere maintenance.
DNA Repair (Amst),2017 Aug56:
Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats.
Front Physiol,20178:
A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System.
PLoS One,201712(1):
Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.
EMBO Mol Med,2017 Jan9(1):
2016
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.
Mol Cell,2016 Dec 1564(6):
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication.
EMBO Rep,2016 Dec17(12):
POLD3 Is Haploinsufficient for DNA Replication in Mice.
Mol Cell,2016 Sep 163(5):
R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders.
EMBO Rep,2016 May17(5):
2015
Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.
Cell Cycle,201514(11):
DNA replication stress as a hallmark of cancer.
Annu Rev Pathol,201510:
DNA replication stress as an Achilles' heel of cancer.
Oncotarget,2015 Jan 16(1):
2014
Conservative DNA replication.
Nat Rev Mol Cell Biol,2014 May15(5):
DOI: 10.1038/nrm3784
Reversal of the DNA-binding-induced loop L1 conformational switch in an engineered human p53 protein.
J Mol Biol,2014 Feb 20426(4):
PARP inhibitors and IR join forces to strike glioblastoma-initiating cells.
Cell Death Differ,2014 Feb21(2):
DOI: 10.1038/cdd.2013.172
Break-induced replication repair of damaged forks induces genomic duplications in human cells.
Science,2014 Jan 3343(6166):
2013
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Nat Cell Biol,2013 Aug15(8):
DOI: 10.1038/ncb2795
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Oncogene,2013 Aug 132(31):
DOI: 10.1038/onc.2012.381
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
Nat Commun,20134:
DOI: 10.1038/ncomms2800
2012
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
Cancer Res,2012 Dec 172(23):
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
Carcinogenesis,2012 Jun33(6):
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
PLoS Genet,2012 Feb8(2):
2011
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
Nat Genet,2011 Dec 2544(2):
DOI: 10.1038/ng.1026
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element.
Mol Cancer Res,2011 Nov9(11):
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.
Mol Oncol,2011 Aug5(4):
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
EMBO J,2011 Jun 130(11):
Genomic instability in induced stem cells.
Cell Death Differ,2011 May18(5):
DOI: 10.1038/cdd.2011.9
SAHF, to senesce or not to senesce?
Cell Cycle,2011 Mar 110(5):
2010
Oncogene-induced senescence: the bright and dark side of the response.
Curr Opin Cell Biol,2010 Dec22(6):
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
EMBO J,2010 Nov 329(21):
Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun,2010 Aug 166(Pt 8):
DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.
J Cell Biol,2010 Jun 28189(7):
14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation.
Cancer Res,2010 Jun 170(11):
Genomic instability--an evolving hallmark of cancer.
Nat Rev Mol Cell Biol,2010 Mar11(3):
DOI: 10.1038/nrm2858
2009
Emerging common themes in regulation of PIKKs and PI3Ks.
EMBO J,2009 Oct 2128(20):
Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction.
Acta Crystallogr D Biol Crystallogr,2009 Sep65(Pt 9):
Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays.
Radiat Res,2009 Aug172(2):
DOI: 10.1667/RR1483.1
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.
Am J Pathol,2009 Jul175(1):
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.
Mol Cell Biol,2009 Feb29(4):
DOI: 10.1128/MCB.01011-08
2008
An oncogene-induced DNA damage model for cancer development.
Science,2008 Mar 7319(5868):
2007
Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.
Mol Cancer Res,2007 Dec5(12):
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Cancer Res,2007 Nov 1567(22):
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
Cancer Res,2007 Jul 167(13):
Evaluation of claspin as a proliferation marker in human cancer and normal tissues.
J Pathol,2007 Feb211(3):
DOI: 10.1002/path.2095
2006
DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter.
Mol Cell,2006 Dec 2824(6):
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Nature,2006 Nov 30444(7119):
DOI: 10.1038/nature05268
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Mol Cell,2006 Aug 423(3):
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.
DNA Repair (Amst),2006 May 105(5):
2005
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.
Cancer Res,2005 Sep 165(17):
Human LATS1 is a mitotic exit network kinase.
Cancer Res,2005 Aug 165(15):
ATM signaling and 53BP1.
Radiother Oncol,2005 Aug76(2):
Nbs1 moving up in the world.
Nat Cell Biol,2005 Jul7(7):
DOI: 10.1038/ncb0705-648
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Nature,2005 Apr 14434(7035):
DOI: 10.1038/nature03485
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus.
Oncogene,2005 Apr 1424(16):
2004
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
Nature,2004 Nov 18432(7015):
DOI: 10.1038/nature03114
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.
EMBO J,2004 Sep 1523(18):
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
J Cell Biol,2004 Sep 13166(6):
Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer.
DNA Repair (Amst),2004 Aug-Sep3(8-9):
53BP1, an activator of ATM in response to DNA damage.
DNA Repair (Amst),2004 Aug-Sep3(8-9):
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
Structure,2004 Jul12(7):
p53 and stress in the ER.
Genes Dev,2004 Feb 118(3):
DOI: 10.1101/gad.1181704
2003
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
Cancer Res,2003 Dec 1563(24):
Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.
Cancer Res,2003 Nov 163(21):
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.
Oncogene,2003 Oct 1622(46):
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis,2003 Jan24(1):
2002
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.
Nat Cell Biol,2002 Dec4(12):
DOI: 10.1038/ncb892
Chk2 leaves the PML depot.
Nat Cell Biol,2002 Nov4(11):
DOI: 10.1038/ncb1102-e255
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure,2002 Jul10(7):
2001
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.
Mol Cell,2001 Dec8(6):
Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest.
Cancer Res,2001 Oct 161(19):
2000
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.
J Cell Biol,2000 Dec 25151(7):
A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.
Oncogene,2000 Oct 1919(44):
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Cell Growth Differ,2000 Sep11(9):
Chfr defines a mitotic stress checkpoint that delays entry into metaphase.
Nature,2000 Jul 27406(6794):
DOI: 10.1038/35019108
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.
Genes Dev,2000 Feb 114(3):
The DNA damage checkpoint and human cancer.
Cold Spring Harb Symp Quant Biol,200065:
1999
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
Proc Natl Acad Sci U S A,1999 Nov 2396(24):
Many faces of ATM: eighth international workshop on ataxia-telangiectasia.
Biochim Biophys Acta,1999 Oct 291424(2-3):
Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions.
Protein Sci,1999 Sep8(9):
DOI: 10.1110/ps.8.9.1773
Involvement of a p53-dependent pathway in rubella virus-induced apoptosis.
Virology,1999 Jun 20259(1):
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.
Mol Cell Biol,1999 Feb19(2):
Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.
Anticancer Res,1999 Jan-Feb19(1A):
1998
Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.
Am J Pathol,1998 Dec153(6):
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.
Nat Genet,1998 Jun19(2):
DOI: 10.1038/542
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding.
Proc Natl Acad Sci U S A,1998 May 2695(11):
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
Br J Cancer,199877(3):
1997
Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.
EMBO J,1997 Oct 1516(20):
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.
Cancer Res,1997 Sep 157(17):
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity.
Oncogene,1997 Aug 1415(7):
1996
Structure-based rescue of common tumor-derived p53 mutants.
Nat Med,1996 Oct2(10):
An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants.
Cancer Res,1996 Jan 156(1):
1995
Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA-sequence of the first intron of the h-ras oncogene.
Int J Oncol,1995 Nov7(5):
Specific recognition of a transcriptional element within the human h-ras protooncogene by the p53 tumor-suppressor.
Int J Oncol,1995 Nov7(5):
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.
EMBO J,1995 Feb 114(3):
1993
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
EMBO J,1993 Dec 1512(13):
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
EMBO J,1993 Mar12(3):
Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.
Oncogene,1993 Jan8(1):
1992
An enhancer "core" DNA-binding and transcriptional activity is induced upon transformation of rat embryo fibroblasts.
Anticancer Res,1992 Mar-Apr12(2):
Predicted structural similarities of the DNA binding domains of c-Myc and endonuclease Eco RI.
Science,1992 Jan 24255(5043):
1991
Proximal regulatory domains of rat atrial natriuretic factor gene.
Circulation,1991 Sep84(3):
Familial holoprosencephaly associated with a translocation breakpoint at chromosomal position 7q36.
Am J Med Genet,1991 Aug 140(2):
Determination of the c-MYC DNA-binding site.
Proc Natl Acad Sci U S A,1991 Jul 1588(14):
1990
Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.
Proc Natl Acad Sci U S A,1990 Aug87(16):
1989
Relationship of clinical parameters to attachment loss in subsets of subjects with destructive periodontal diseases.
J Clin Periodontol,1989 Oct16(9):
1988
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.
Cell,1988 Dec 255(5):
Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay.
Mol Cell Biol,1988 Apr8(4):
1987
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity.
Proc Natl Acad Sci U S A,1987 Jan84(1):
1986
Posterior capsulitis in a 9-year-old girl.
J Pedod,1986 Winter10(2):
1985
Clinical medicine for dental students.
J Dent Educ,1985 Dec49(12):
Pocket formation 3 years after comprehensive periodontal therapy. A retrospective study.
J Periodontol,1985 Sep56(9):