Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains.

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.

EGOC inhibits TOROID polymerization by structurally activating TORC1.

Dynamic metabolome profiling uncovers potential TOR signaling genes.

Ultrastructure expansion microscopy reveals the cellular architecture of budding and fission yeast.

Cryo-EM structure of the SEA complex.

Chemical-Biology-derived in vivo Sensors: Past, Present, and Future.

Flipper Probes for the Community.

Passive coupling of membrane tension and cell volume during active response of cells to osmosis.

Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides.

Phosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55.

Resolving the Communication GAPs Upstream of TORC1.

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast.

Structural Insights into TOR Signaling.

The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance.

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9.

The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast.

Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.

TORC2 controls endocytosis through plasma membrane tension.

Sphingolipids and membrane targets for therapeutics.

TOR Signaling Is Going through a Phase.

Regulation of Cellular Metabolism through Phase Separation of Enzymes.

Decrease in plasma membrane tension triggers PtdIns(4,5)P(2) phase separation to inactivate TORC2.

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Systematic analysis of complex genetic interactions.

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Tensing Up for Lipid Droplet Formation.

A pathway of targeted autophagy is induced by DNA damage in budding yeast.

Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

TORC2 Structure and Function.

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

TOR Complexes and the Maintenance of Cellular Homeostasis.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.

Roles for PI(3,5)P2 in nutrient sensing through TORC1.

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Growth control: function follows form.

Amino acid signaling in high definition.

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

Target of rapamycin (TOR) in nutrient signaling and growth control.

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.

A brief history of TOR.

Chemical biology approaches to membrane homeostasis and function.

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway.

The Vam6 GEF controls TORC1 by activating the EGO complex.

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.

Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.

Caffeine extends yeast lifespan by targeting TORC1.

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

Mutual antagonism of target of rapamycin and calcineurin signaling.

Cell growth control: little eukaryotes make big contributions.

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

TOR signaling in growth and metabolism.

The TOR signalling network from yeast to man.

Molecular organization of target of rapamycin complex 2.

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Human ING1 proteins differentially regulate histone acetylation.

Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.

Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.

Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe.

Mammalian CAP interacts with CAP, CAP2, and actin.