EGOC inhibits TOROID polymerization by structurally activating TORC1.
Nat Struct Mol Biol,2023 Jan 26:
Dynamic metabolome profiling uncovers potential TOR signaling genes.
Elife,2023 Jan 412:
Ultrastructure expansion microscopy reveals the cellular architecture of budding and fission yeast.
J Cell Sci,2022 Dec 15135(24):
Cryo-EM structure of the SEA complex.
Chemical-Biology-derived in vivo Sensors: Past, Present, and Future.
Chimia (Aarau),2021 Dec 2275(12):
Flipper Probes for the Community.
Chimia (Aarau),2021 Dec 2275(12):
Passive coupling of membrane tension and cell volume during active response of cells to osmosis.
Proc Natl Acad Sci U S A,2021 Nov 23118(47):
Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides.
ACS Cent Sci,2021 Jun 237(6):
Phosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55.
Resolving the Communication GAPs Upstream of TORC1.
Dev Cell,2020 Nov 955(3):
TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast.
J Biol Chem,2020 Aug 21295(34):
Structural Insights into TOR Signaling.
Genes (Basel),2020 Aug 411(8):
The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance.
J Cell Sci,2020 May 11133(9):
Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9.
Mol Cell Proteomics,2020 Apr19(4):
The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast.
Mol Cell,2020 Mar 577(5):
Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.
Dev Cell,2019 Nov 1851(4):
TORC2 controls endocytosis through plasma membrane tension.
J Cell Biol,2019 Jul 1218(7):
Sphingolipids and membrane targets for therapeutics.
Curr Opin Chem Biol,2019 Jun50:
TOR Signaling Is Going through a Phase.
Cell Metab,2019 May 729(5):
Regulation of Cellular Metabolism through Phase Separation of Enzymes.
Biomolecules,2018 Dec 38(4):
Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nat Cell Biol,2018 Sep20(9):
Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.
J Biol Chem,2018 Aug 3293(31):
Systematic analysis of complex genetic interactions.
Science,2018 Apr 20360(6386):
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Nat Commun,2017 Nov 238(1):
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
Nature,2017 Oct 12550(7675):
Tensing Up for Lipid Droplet Formation.
Dev Cell,2017 Jun 1941(6):
A pathway of targeted autophagy is induced by DNA damage in budding yeast.
Proc Natl Acad Sci U S A,2017 Feb 14114(7):
Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.
J Biol Chem,2017 Jan 13292(2):
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
Nat Chem Biol,2016 Oct12(10):
TORC2 Structure and Function.
Trends Biochem Sci,2016 Jun41(6):
A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.
Sci Rep,2016 Jan 136:
TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.
Mol Biol Cell,2016 Jan 1527(2):
TOR Complexes and the Maintenance of Cellular Homeostasis.
Trends Cell Biol,2016 Feb26(2):
Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Mol Cell,2015 Jun 1858(6):
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.
J Biol Chem,2015 Jun 12290(24):
Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.
Mol Biol Cell,2014 Oct 1525(20):
Roles for PI(3,5)P2 in nutrient sensing through TORC1.
Mol Biol Cell,2014 Apr25(7):
A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
PLoS Genet,2014 Jan10(1):
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
Mol Cell,2013 Sep 2651(6):
Growth control: function follows form.
Curr Biol,2013 Jul 2223(14):
Amino acid signaling in high definition.
Structure,2012 Dec 520(12):
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
ACS Chem Biol,2012 Apr 207(4):
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
Nat Cell Biol,2012 Apr 1514(5):
Target of rapamycin (TOR) in nutrient signaling and growth control.
Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.
Eukaryot Cell,2011 Oct10(10):
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.
EMBO J,2011 Jul 530(15):
A brief history of TOR.
Biochem Soc Trans,2011 Apr39(2):
Chemical biology approaches to membrane homeostasis and function.
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
Sci Signal,2010 Dec 213(153):
Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway
The Vam6 GEF controls TORC1 by activating the EGO complex.
Mol Cell,2009 Sep 1135(5):
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
Genes Dev,2009 Aug 1523(16):
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.
Mol Biol Cell,2009 Apr20(7):
Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Mol Cell,2009 Mar 2733(6):
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
PLoS Biol,2009 Feb 107(2):
Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.
Mol Biol Cell,2009 Feb20(3):
Caffeine extends yeast lifespan by targeting TORC1.
Mol Microbiol,2008 Jul69(1):
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Mol Cell,2007 Jun 826(5):
Mutual antagonism of target of rapamycin and calcineurin signaling.
J Biol Chem,2006 Nov 3281(44):
Cell growth control: little eukaryotes make big contributions.
Oncogene,2006 Oct 1625(48):
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell,2006 May 19125(4):
TOR signaling in growth and metabolism.
Cell,2006 Feb 10124(3):
The TOR signalling network from yeast to man.
Int J Biochem Cell Biol,200638(9):
Molecular organization of target of rapamycin complex 2.
J Biol Chem,2005 Sep 2280(35):
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Mol Cell Biol,2005 Aug25(16):
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Nat Cell Biol,2004 Nov6(11):
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.
EMBO J,2004 Oct 123(19):
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Mol Cell,2002 Sep10(3):
Human ING1 proteins differentially regulate histone acetylation.
J Biol Chem,2002 Aug 16277(33):
Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.
J Biol Chem,2001 Jun 29276(26):
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.
Mol Cell Biol,2000 Jun20(11):
Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe.
J Cell Sci,2000 Jan113 ( Pt 1:
Mammalian CAP interacts with CAP, CAP2, and actin.
J Cell Biochem,1996 Jun 161(3):