Ramesh Pillai

Publications

2022

The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition.
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Mol Cell, ; 82 (9):

2021

YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.
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Cell Rep, ; 37 (11):
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
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Cell, ; 184 (12):

2020

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
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Cell Rep, ; 32 (7):
TEX15 associates with MILI and silences transposable elements in male germ cells.
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Genes Dev, ; 34 (11-12):

2019

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
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Cell Rep, ; 29 (13):
Nxf3: a middleman with the right connections for unspliced piRNA precursor export.
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Genes Dev, ; 33 (17-18):
Counting the Cuts: MAZTER-Seq Quantifies m6A Levels Using a Methylation-Sensitive Ribonuclease.
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Cell, ; 178 (3):

2018

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.
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Mol Cell, ; 71 (6):
Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12.
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Cell Rep, ; 24 (13):

2017

Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.
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Mol Cell, ; 68 (2):
Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
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EMBO J, ; 36 (17):
Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries.
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PLoS Genet, ; 13 (8):
Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function.
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Dev Cell, ; 41 (6):
Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease.
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RNA, ; 23 (9):

2016

Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice.
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Biol Reprod, ; 95 (5):
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.
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Mol Cell, ; 61 (1):

2015

PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis.
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Cell Rep, ; 12 (3):
Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.
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RNA, ; 21 (5):
The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.
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Genes Dev, ; 29 (6):

2014

RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts.
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Cell, ; 157 (7):
The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs.
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RNA, ; 20 (6):
Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries.
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Nucleic Acids Res, ; 42 (10):
Analysis of small RNA-guided endonuclease activity in endogenous Piwi protein complexes from mouse testes.
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Methods Mol Biol, ; 1093 :

2013

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
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Proc Natl Acad Sci U S A, ; 110 (41):
[The piRNAs forge an immune system for the genome].
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Med Sci (Paris), ; 29 (5):

2012

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc.
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RNA, ; 18 (12):
The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.
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RNA, ; 18 (11):
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.
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Mol Cell, ; 47 (6):

2011

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.
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Nature, ; 480 (7376):
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
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Proc Natl Acad Sci U S A, ; 108 (26):
Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein.
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Structure, ; 19 (2):

2010

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.
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Proc Natl Acad Sci U S A, ; 107 (26):

2009

Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries.
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PLoS Genet, ; 5 (12):
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
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Dev Cell, ; 17 (6):
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.
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Nat Struct Mol Biol, ; 16 (6):

2007

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F.
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Science, ; 317 (5845):
Repression of protein synthesis by miRNAs: how many mechanisms?
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Trends Cell Biol, ; 17 (3):

2006

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells.
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Nucleic Acids Res, ; 34 (17):

2005

MicroRNA function: multiple mechanisms for a tiny RNA?
RNA, ; 11 (12):
Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.
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J Biol Chem, ; 280 (41):
Inhibition of translational initiation by Let-7 MicroRNA in human cells.
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Science, ; 309 (5740):
The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.
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Chromosoma, ; 114 (3):
Post-transcriptional gene silencing by siRNAs and miRNAs.
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Curr Opin Struct Biol, ; 15 (3):

2004

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.
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RNA, ; 10 (10):
The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.
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Cell Mol Life Sci, ; 61 (19-20):

2003

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.
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Genes Dev, ; 17 (18):

2001

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs.
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Nat Cell Biol, ; 3 (11):
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.
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EMBO J, ; 20 (19):