Publications

The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m⁶A recognition.

Li L, Krasnykov K, Homolka D, Gos P, Mendel M, Fish RJ, Pandey RR, Pillai RS

Mol Cell, 2022 May 5; 82 (9):

DOI: 10.1016/j.molcel.2022.02.034

YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.

Liu R, Kasowitz SD, Homolka D, Leu NA, Shaked JT, Ruthel G, Jain D, Lin H, Keeney S, Luo M, Pillai RS, Wang PJ

Cell Rep, 2021 Dec 14; 37 (11):

DOI: 10.1016/j.celrep.2021.110110

[ Pubmed ]

Splice site m⁶A methylation prevents binding of U2AF35 to inhibit RNA splicing.

Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS

Cell, 2021 Jun 10; 184 (12):

DOI: 10.1016/j.cell.2021.03.062

[ Pubmed ]

The Mammalian Cap-Specific m⁶Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.

Pandey RR, Delfino E, Homolka D, Roithova A, Chen KM, Li L, Franco G, Vågbø CB, Taillebourg E, Fauvarque MO, Pillai RS

Cell Rep, 2020 Aug 18; 32 (7):

DOI: 10.1016/j.celrep.2020.108038

[ Pubmed ]

TEX15 associates with MILI and silences transposable elements in male germ cells.

Yang F, Lan Y, Pandey RR, Homolka D, Berger SL, Pillai RS, Bartolomei MS, Wang PJ

Genes Dev, 2020 Jun 1; 34 (11-12):

DOI: 10.1101/gad.335489.119

[ Pubmed ]

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

Wu H, Li L, Chen KM, Homolka D, Gos P, Fleury-Olela F, McCarthy AA, Pillai RS

Cell Rep, 2019 Dec 24; 29 (13):

DOI: 10.1016/j.celrep.2019.11.108

[ Pubmed ]

An RNA exporter that enforces a no-export policy.

Homolka D, Pillai RS

Nat Struct Mol Biol, 2019 Sep; 26 (9):

DOI: 10.1038/s41594-019-0294-y

[ Pubmed ]

Nxf3: a middleman with the right connections for unspliced piRNA precursor export.

Mendel M, Pillai RS

Genes Dev, 2019 Sep 1; 33 (17-18):

DOI: 10.1101/gad.330530.119

[ Pubmed ]

Counting the Cuts: MAZTER-Seq Quantifies m⁶A Levels Using a Methylation-Sensitive Ribonuclease.

Pandey RR, Pillai RS

Cell, 2019 Jul 25; 178 (3):

DOI: 10.1016/j.cell.2019.07.006

[ Pubmed ]

Methylation of Structured RNA by the m⁶A Writer METTL16 Is Essential for Mouse Embryonic Development.

Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS

Mol Cell, 2018 Sep 20; 71 (6):

DOI: 10.1016/j.molcel.2018.08.004

[ Pubmed ]

Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12.

Pandey RR, Homolka D, Olotu O, Sachidanandam R, Kotaja N, Pillai RS

Cell Rep, 2018 Sep 25; 24 (13):

DOI: 10.1016/j.celrep.2018.08.087

[ Pubmed ]

Regulation of m⁶A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.

Wojtas MN, Pandey RR, Mendel M, Homolka D, Sachidanandam R, Pillai RS

Mol Cell, 2017 Oct 19; 68 (2):

DOI: 10.1016/j.molcel.2017.09.021

[ Pubmed ]

Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L, Shichino Y, Dangin M, Thierry-Mieg N, Gilquin B, Hiriart E, Sachidanandam R, Lambert E, Brettschneider J, Reuter M, Kadlec J, Pillai R, Yamashita A, Yamamoto M, Verdel A

EMBO J, 2017 Sep 1; 36 (17):

DOI: 10.15252/embj.201796571

[ Pubmed ]

Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries.

Pandey RR, Homolka D, Chen KM, Sachidanandam R, Fauvarque MO, Pillai RS

PLoS Genet, 2017 Aug; 13 (8):

DOI: 10.1371/journal.pgen.1006956

[ Pubmed ]

Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function.

Wenda JM, Homolka D, Yang Z, Spinelli P, Sachidanandam R, Pandey RR, Pillai RS

Dev Cell, 2017 Jun 19; 41 (6):

DOI: 10.1016/j.devcel.2017.05.021

[ Pubmed ]

Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease.

Silva S, Homolka D, Pillai RS

RNA, 2017 Sep; 23 (9):

DOI: 10.1261/rna.060723.117

[ Pubmed ]

Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice.

Fu Q, Pandey RR, Leu NA, Pillai RS, Wang PJ

Biol Reprod, 2016 Nov 1; 95 (5):

DOI: 10.1095/biolreprod.116.142430

[ Pubmed ]

PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.

Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS

Mol Cell, 2016 Jan 7; 61 (1):

DOI: 10.1016/j.molcel.2015.11.009

[ Pubmed ]

PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis.

Homolka D, Pandey RR, Goriaux C, Brasset E, Vaury C, Sachidanandam R, Fauvarque MO, Pillai RS

Cell Rep, 2015 Jul 21; 12 (3):

DOI: 10.1016/j.celrep.2015.06.030

[ Pubmed ]

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.

Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS

RNA, 2015 May; 21 (5):

DOI: 10.1261/rna.049437.114

[ Pubmed ]

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.

Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, Pillai RS, Mourelatos Z, Wang PJ

Genes Dev, 2015 Mar 15; 29 (6):

DOI: 10.1101/gad.254631.114

[ Pubmed ]

Fly piRNA biogenesis: tap dancing with Tej.

Yang Z, Pillai RS

BMC Biol, 2014 Oct 6; 12 :

DOI: 10.1186/s12915-014-0077-1

[ Pubmed ]

Primary piRNA biogenesis: caught up in a Maelstrom.

Pandey RR, Pillai RS

EMBO J, 2014 Sep 17; 33 (18):

DOI: 10.15252/embj.201489670

[ Pubmed ]

RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts.

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS

Cell, 2014 Jun 19; 157 (7):

DOI: 10.1016/j.cell.2014.05.018

[ Pubmed ]

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs.

Cora E, Pandey RR, Xiol J, Taylor J, Sachidanandam R, McCarthy AA, Pillai RS

RNA, 2014 Jun; 20 (6):

DOI: 10.1261/rna.044701.114

[ Pubmed ]

Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries.

Klenov MS, Lavrov SA, Korbut AP, Stolyarenko AD, Yakushev EY, Reuter M, Pillai RS, Gvozdev VA

Nucleic Acids Res, 2014 Jun; 42 (10):

DOI: 10.1093/nar/gku268

[ Pubmed ]

Analysis of small RNA-guided endonuclease activity in endogenous Piwi protein complexes from mouse testes.

Reuter M, Pillai RS

Methods Mol Biol, 2014; 1093 :

DOI: 10.1007/978-1-62703-694-8_9

[ Pubmed ]

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.

Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS

Proc Natl Acad Sci U S A, 2013 Oct 8; 110 (41):

DOI: 10.1073/pnas.1316316110

[ Pubmed ]

[The piRNAs forge an immune system for the genome].

Muller S, Raman Pandey R, Pillai RS

Med Sci (Paris), 2013 May; 29 (5):

DOI: 10.1051/medsci/2013295011

[ Pubmed ]

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc.

Voigt F, Reuter M, Kasaruho A, Schulz EC, Pillai RS, Barabas O

RNA, 2012 Dec; 18 (12):

DOI: 10.1261/rna.034967.112

[ Pubmed ]

The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.

Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S

RNA, 2012 Nov; 18 (11):

DOI: 10.1261/rna.034181.112

[ Pubmed ]

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.

Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS

Mol Cell, 2012 Sep 28; 47 (6):

DOI: 10.1016/j.molcel.2012.07.019

[ Pubmed ]

Molecular biology. Outsourcing genome protection.

Xiol J, Pillai RS

Science, 2012 Aug 3; 337 (6094):

DOI: 10.1126/science.1227095

[ Pubmed ]

piRNAs and their involvement in male germline development in mice.

Pillai RS, Chuma S

Dev Growth Differ, 2012 Jan; 54 (1):

DOI: 10.1111/j.1440-169X.2011.01320.x

[ Pubmed ]

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.

Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS

Nature, 2011 Nov 27; 480 (7376):

DOI: 10.1038/nature10672

[ Pubmed ]

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S

Proc Natl Acad Sci U S A, 2011 Jun 28; 108 (26):

DOI: 10.1073/pnas.1015447108

[ Pubmed ]

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein.

Simon B, Kirkpatrick JP, Eckhardt S, Reuter M, Rocha EA, Andrade-Navarro MA, Sehr P, Pillai RS, Carlomagno T

Structure, 2011 Feb 9; 19 (2):

DOI: 10.1016/j.str.2010.11.015

[ Pubmed ]

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

Zheng K, Xiol J, Reuter M, Eckardt S, Leu NA, McLaughlin KJ, Stark A, Sachidanandam R, Pillai RS, Wang PJ

Proc Natl Acad Sci U S A, 2010 Jun 29; 107 (26):

DOI: 10.1073/pnas.1003953107

[ Pubmed ]

Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries.

Chuma S, Pillai RS

PLoS Genet, 2009 Dec; 5 (12):

DOI: 10.1371/journal.pgen.1000770

[ Pubmed ]

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.

Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S

Dev Cell, 2009 Dec; 17 (6):

DOI: 10.1016/j.devcel.2009.10.012

[ Pubmed ]

Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.

Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS

Nat Struct Mol Biol, 2009 Jun; 16 (6):

DOI: 10.1038/nsmb.1615

[ Pubmed ]

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F.

Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N

Science, 2007 Sep 21; 317 (5845):

DOI: 10.1126/science.1146067

[ Pubmed ]

Repression of protein synthesis by miRNAs: how many mechanisms?

Pillai RS, Bhattacharyya SN, Filipowicz W

Trends Cell Biol, 2007 Mar; 17 (3):

DOI: 10.1016/j.tcb.2006.12.007

[ Pubmed ]

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells.

Schmitter D, Filkowski J, Sewer A, Pillai RS, Oakeley EJ, Zavolan M, Svoboda P, Filipowicz W

Nucleic Acids Res, 2006; 34 (17):

DOI: 10.1093/nar/gkl646

[ Pubmed ]

MicroRNA function: multiple mechanisms for a tiny RNA?

Pillai RS

RNA, 2005 Dec; 11 (12):

DOI: 10.1261/rna.2248605

[ Pubmed ]

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D

J Biol Chem, 2005 Oct 14; 280 (41):

DOI: 10.1074/jbc.M505077200

[ Pubmed ]

Inhibition of translational initiation by Let-7 MicroRNA in human cells.

Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W

Science, 2005 Sep 2; 309 (5740):

DOI: 10.1126/science.1115079

[ Pubmed ]

The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.

Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG

Chromosoma, 2005 Aug; 114 (3):

DOI: 10.1007/s00412-005-0003-y

[ Pubmed ]

Post-transcriptional gene silencing by siRNAs and miRNAs.

Filipowicz W, Jaskiewicz L, Kolb FA, Pillai RS

Curr Opin Struct Biol, 2005 Jun; 15 (3):

DOI: 10.1016/j.sbi.2005.05.006

[ Pubmed ]

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.

Pillai RS, Artus CG, Filipowicz W

RNA, 2004 Oct; 10 (10):

DOI: 10.1261/rna.7131604

[ Pubmed ]

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.

Schümperli D, Pillai RS

Cell Mol Life Sci, 2004 Oct; 61 (19-20):

DOI: 10.1007/s00018-004-4190-0

[ Pubmed ]

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D

Genes Dev, 2003 Sep 15; 17 (18):

DOI: 10.1101/gad.274403

[ Pubmed ]

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs.

Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U

Nat Cell Biol, 2001 Nov; 3 (11):

DOI: 10.1038/ncb1101-945

[ Pubmed ]

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B

EMBO J, 2001 Oct 1; 20 (19):

DOI: 10.1093/emboj/20.19.5470

[ Pubmed ]

Ramesh Pillai

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2007

2006

2005

2004

2003

2001