Publications

2023

SUMO in the regulation of DNA repair and transcription at nuclear pores.

Gasser SM, Stutz F

FEBS Lett,2023 Oct 7:

DOI: 10.1002/1873-3468.14751

Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast.

Noireterre A, Serbyn N, Bagdiul I, Stutz F

EMBO J,2023 Jul 342(13):

DOI: 10.15252/embj.2023113609

2022

Antisense non-coding transcription represses the PHO5 model gene at the level of promoter chromatin structure.

Novačić A, Menéndez D, Ljubas J, Barbarić S, Stutz F, Soudet J, Stuparević I

PLoS Genet,2022 Oct 1018(10):

DOI: 10.1371/journal.pgen.1010432

Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone.

Soudet J, Beyrouthy N, Pastucha AM, Maffioletti A, Menéndez D, Bakir Z, Stutz F

Nucleic Acids Res,2022 May 650(8):

DOI: 10.1093/nar/gkac264

2021

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways.

Serbyn N, Bagdiul I, Noireterre A, Michel AH, Suhandynata RT, Zhou H, Kornmann B, Stutz F

Cell Rep,2021 Nov 2337(8):

DOI: 10.1016/j.celrep.2021.110034

2020

Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription.

Gill JK, Maffioletti A, García-Molinero V, Stutz F, Soudet J

Cell Rep,2020 May 531(5):

DOI: 10.1016/j.celrep.2020.107612

The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast.

Serbyn N, Noireterre A, Bagdiul I, Plank M, Michel AH, Loewith R, Kornmann B, Stutz F

Mol Cell,2020 Mar 577(5):

DOI: 10.1016/j.molcel.2019.12.007

The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair.

Infantino V, Stutz F

Curr Genet,2020 Feb66(1):

DOI: 10.1007/s00294-019-01011-8

2019

Regulation of Gene Expression and Replication Initiation by Non-Coding Transcription: A Model Based on Reshaping Nucleosome-Depleted Regions: Influence of Pervasive Transcription on Chromatin Structure.

Soudet J, Stutz F

Bioessays,2019 Nov41(11):

DOI: 10.1002/bies.201900043

The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain.

Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F

PLoS One,201914(4):

DOI: 10.1371/journal.pone.0206336

2018

Noncoding transcription influences the replication initiation program through chromatin regulation.

Soudet J, Gill JK, Stutz F

Genome Res,2018 Dec28(12):

DOI: 10.1101/gr.239582.118

2017

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function.

Gali VK, Balint E, Serbyn N, Frittmann O, Stutz F, Unk I

Sci Rep,2017 Oct 127(1):

DOI: 10.1038/s41598-017-12915-1

2015

Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation.

Castelnuovo M, Stutz F

Curr Opin Cell Biol,2015 Jun34:

DOI: 10.1016/j.ceb.2015.04.011

Sumoylation and transcription regulation at nuclear pores.

Texari L, Stutz F

Chromosoma,2015 Mar124(1):

DOI: 10.1007/s00412-014-0481-x

2014

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast.

Castelnuovo M, Zaugg JB, Guffanti E, Maffioletti A, Camblong J, Xu Z, Clauder-Münster S, Steinmetz LM, Luscombe NM, Stutz F

Nucleic Acids Res,2014 Apr42(7):

DOI: 10.1093/nar/gku100

2013

The nuclear pore regulates GAL1 gene transcription by controlling the localization of the SUMO protease Ulp1.

Texari L, Dieppois G, Vinciguerra P, Contreras MP, Groner A, Letourneau A, Stutz F

Mol Cell,2013 Sep 2651(6):

DOI: 10.1016/j.molcel.2013.08.047

Bimodal expression of PHO84 is modulated by early termination of antisense transcription.

Castelnuovo M, Rahman S, Guffanti E, Infantino V, Stutz F, Zenklusen D

Nat Struct Mol Biol,2013 Jul20(7):

DOI: 10.1038/nsmb.2598

Gene loops and HDACs to promote transcription directionality.

Castelnuovo M, Stutz F

Nucleus,2013 Mar-Apr4(2):

DOI: 10.4161/nucl.24236

2012

Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export.

Brockmann C, Soucek S, Kuhlmann SI, Mills-Lujan K, Kelly SM, Yang JC, Iglesias N, Stutz F, Corbett AH, Neuhaus D, Stewart M

Structure,2012 Jun 620(6):

DOI: 10.1016/j.str.2012.03.011

Ubiquitin and assembly of export competent mRNP.

Babour A, Dargemont C, Stutz F

Biochim Biophys Acta,2012 Jun1819(6):

DOI: 10.1016/j.bbagrm.2011.12.006

2011

Keeping mRNPs in check during assembly and nuclear export.

Tutucci E, Stutz F

Nat Rev Mol Cell Biol,2011 Jun12(6):

DOI: 10.1038/nrm3119

2010

Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export.

Iglesias N, Tutucci E, Gwizdek C, Vinciguerra P, Von Dach E, Corbett AH, Dargemont C, Stutz F

Genes Dev,2010 Sep 124(17):

DOI: 10.1101/gad.583310

Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression.

Dieppois G, Stutz F

J Cell Sci,2010 Jun 15123(Pt 12):

DOI: 10.1242/jcs.053694

2009

Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae.

Camblong J, Beyrouthy N, Guffanti E, Schlaepfer G, Steinmetz LM, Stutz F

Genes Dev,2009 Jul 123(13):

DOI: 10.1101/gad.522509

Bidirectional promoters generate pervasive transcription in yeast.

Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM

Nature,2009 Feb 19457(7232):

DOI: 10.1038/nature07728

2008

THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.

Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F, Libri D

Cell,2008 Oct 17135(2):

DOI: 10.1016/j.cell.2008.08.005

Regulation of mRNP dynamics along the export pathway.

Iglesias N, Stutz F

FEBS Lett,2008 Jun 18582(14):

DOI: 10.1016/j.febslet.2008.03.038

2007

Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae.

Camblong J, Iglesias N, Fickentscher C, Dieppois G, Stutz F

Cell,2007 Nov 16131(4):

DOI: 10.1016/j.cell.2007.09.014

Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67.

Hobeika M, Brockmann C, Iglesias N, Gwizdek C, Neuhaus D, Stutz F, Stewart M, Divita G, Dargemont C

Mol Biol Cell,2007 Jul18(7):

DOI: 10.1091/mbc.e07-02-0153

2006

Cotranscriptional recruitment to the mRNA export receptor Mex67p contributes to nuclear pore anchoring of activated genes.

Dieppois G, Iglesias N, Stutz F

Mol Cell Biol,2006 Nov26(21):

DOI: 10.1128/MCB.00870-06

Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription.

Gwizdek C, Iglesias N, Rodriguez MS, Ossareh-Nazari B, Hobeika M, Divita G, Stutz F, Dargemont C

Proc Natl Acad Sci U S A,2006 Oct 31103(44):

DOI: 10.1073/pnas.0607941103

2005

Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.

Vinciguerra P, Iglesias N, Camblong J, Zenklusen D, Stutz F

EMBO J,2005 Feb 2324(4):

DOI: 10.1038/sj.emboj.7600527

2004

Nuclear export of RNA.

Rodriguez MS, Dargemont C, Stutz F

Biol Cell,2004 Oct96(8):

DOI: 10.1016/j.biolcel.2004.04.014

mRNA export: an assembly line from genes to nuclear pores.

Vinciguerra P, Stutz F

Curr Opin Cell Biol,2004 Jun16(3):

DOI: 10.1016/j.ceb.2004.03.013

Interactions of processed Nef (58-206) with virion proteins of HIV type 1.

Ciuffi A, Munoz M, Bleiber G, Favre M, Stutz F, Telenti A, Meylan PR

AIDS Res Hum Retroviruses,2004 Apr20(4):

DOI: 10.1089/088922204323048140

2003

Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport.

Cohen M, Stutz F, Dargemont C

J Biol Chem,2003 Dec 26278(52):

DOI: 10.1074/jbc.C300451200

Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23.

Cohen M, Stutz F, Belgareh N, Haguenauer-Tsapis R, Dargemont C

Nat Cell Biol,2003 Jul5(7):

DOI: 10.1038/ncb1003

The interplay of nuclear mRNP assembly, mRNA surveillance and export.

Stutz F, Izaurralde E

Trends Cell Biol,2003 Jun13(6):

DOI: 10.1016/s0962-8924(03)00106-5

2002

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.

Zenklusen D, Vinciguerra P, Wyss JC, Stutz F

Mol Cell Biol,2002 Dec22(23):

DOI: 10.1128/MCB.22.23.8241-8253.2002

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S

J Biol Chem,2002 Nov 22277(47):

DOI: 10.1074/jbc.M207439200

Coupling of termination, 3' processing, and mRNA export.

Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN

Mol Cell Biol,2002 Sep22(18):

DOI: 10.1128/MCB.22.18.6441-6457.2002

2001

mRNA export: travelling with DEAD box proteins.

Linder P, Stutz F

Curr Biol,2001 Nov 2711(23):

DOI: 10.1016/s0960-9822(01)00574-7

The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p.

Zenklusen D, Vinciguerra P, Strahm Y, Stutz F

Mol Cell Biol,2001 Jul21(13):

DOI: 10.1128/MCB.21.13.4219-4232.2001

Nuclear export of mRNA.

Zenklusen D, Stutz F

FEBS Lett,2001 Jun 8498(2-3):

DOI: 10.1016/s0014-5793(01)02482-6

2000

Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.

Künzler M, Gerstberger T, Stutz F, Bischoff FR, Hurt E

Mol Cell Biol,2000 Jun20(12):

DOI: 10.1128/MCB.20.12.4295-4308.2000

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export.

Stutz F, Bachi A, Doerks T, Braun IC, Séraphin B, Wilm M, Bork P, Izaurralde E

RNA,2000 Apr6(4):

DOI: 10.1017/s1355838200000078

1999

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.

Strahm Y, Fahrenkrog B, Zenklusen D, Rychner E, Kantor J, Rosbach M, Stutz F

EMBO J,1999 Oct 1518(20):

DOI: 10.1093/emboj/18.20.5761

1998

Nuclear RNA export.

Stutz F, Rosbash M

Genes Dev,1998 Nov 112(21):

DOI: 10.1101/gad.12.21.3303

1997

The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region.

Stutz F, Kantor J, Zhang D, McCarthy T, Neville M, Rosbash M

Genes Dev,1997 Nov 111(21):

DOI: 10.1101/gad.11.21.2857

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export.

Neville M, Stutz F, Lee L, Davis LI, Rosbash M

Curr Biol,1997 Oct 17(10):

DOI: 10.1016/s0960-9822(06)00335-6

A dynamic in vivo view of the HIV-I Rev-RRE interaction.

Charpentier B, Stutz F, Rosbash M

J Mol Biol,1997 Mar 14266(5):

DOI: 10.1006/jmbi.1996.0858

1996

A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.

Stutz F, Izaurralde E, Mattaj IW, Rosbash M

Mol Cell Biol,1996 Dec16(12):

DOI: 10.1128/MCB.16.12.7144

The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex.

Colot HV, Stutz F, Rosbash M

Genes Dev,1996 Jul 110(13):

DOI: 10.1101/gad.10.13.1699

Françoise Stutz