Positively charged specificity site in cyclin B1 is essential for mitotic fidelity

Together with the Mayer group, the Boland lab revealed that Cyclin B1’s positively charged pocket, unique to B-type cyclins, is crucial for mitosis. It binds phosphorylated residues, enabling proper spindle function and APC/C activation. Mutations in this pocket delay anaphase and disrupt APC/C phosphorylation and activity, highlighting its role in sequential substrate phosphorylations, including non-consensus CDK1 sites.

You can read the full study here: https://www.nature.com/articles/s41467-024-55669-x